Basic Information
ID: ALA4406244
Type: Unassigned
Description: Selectivity index, ratio of IC50 for inhibition of recombinant human N-terminal GST-tagged JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-labeled GEEPLYWSFPAKKK-NH2 peptide as substrate after 10 mins in presence of 5 mM ATP by caliper mobility shift assay to IC50 for inhibition of recombinant human N-terminal GST-tagged JAK1 (866 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH peptide as substrate after 10 mins in presence of 5 mM ATP by caliper mobility shift assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Unchecked(ALA612545)
Document: ALA4402602
Selectivity index, ratio of IC50 for inhibition of recombinant human N-terminal GST-tagged JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-labeled GEEPLYWSFPAKKK-NH2 peptide as substrate after 10 mins in presence of 5 mM ATP by caliper mobility shift assay to IC50 for inhibition of recombinant human N-terminal GST-tagged JAK1 (866 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH peptide as substrate after 10 mins in presence of 5 mM ATP by caliper mobility shift assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4406244
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 306.37 | 3.47 | 3.47 |
| 524.03 | 3.34 | 3.34 |
| 468.52 | 4.37 | 4.37 |
| 304.36 | 3.41 | 3.41 |
| 468.57 | 5.04 | 5.04 |
| 484.61 | 3.95 | 3.95 |
| 503.61 | 2.99 | 2.99 |
| 440.51 | 4.55 | 4.55 |
| 482.55 | 4.68 | 4.68 |
| 488.57 | 3.79 | 3.79 |
| 434.50 | 2.55 | 2.55 |
| 392.46 | 2.78 | 2.78 |
| 452.52 | 4.67 | 4.67 |
| 507.57 | 2.82 | 2.82 |
| 442.91 | 4.33 | 4.33 |
| 461.57 | 2.86 | 2.86 |
| 447.54 | 2.47 | 2.47 |
| 568.48 | 3.45 | 3.45 |
| 489.58 | 2.69 | 2.69 |
| 475.60 | 3.25 | 3.25 |
| 461.57 | 2.86 | 2.86 |