Basic Information
ID: ALA4406533
Type: ADME
Description: Antagonist activity at human D2R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 mins by beta-galactosidase based PathHunter assay relative to sulpiride
Format: BAO_0000219
Organism: Homo sapiens
Target: Dopamine D2 receptor(ALA217)
Document: ALA4402608
Antagonist activity at human D2R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 mins by beta-galactosidase based PathHunter assay relative to sulpiride: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4406533
Imax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 370.45 | 2.54 | 2.54 |
| 340.42 | 2.53 | 2.53 |
| 374.87 | 3.19 | 3.19 |
| 377.49 | 3.57 | 3.57 |
| 364.45 | 2.41 | 2.41 |
| 368.48 | 3.09 | 3.09 |
| 406.50 | 2.09 | 2.09 |
| 351.41 | 1.79 | 1.79 |
| 384.48 | 2.93 | 2.93 |
| 405.54 | 4.30 | 4.30 |
| 409.49 | 3.02 | 3.02 |
| 393.49 | 3.40 | 3.40 |
| 397.91 | 3.97 | 3.97 |
| 380.45 | 2.41 | 2.41 |
| 400.48 | 2.55 | 2.55 |
| 413.91 | 3.67 | 3.67 |
| 395.53 | 3.73 | 3.73 |
| 395.53 | 3.73 | 3.73 |
| 351.41 | 1.79 | 1.79 |
| 409.49 | 3.02 | 3.02 |
| 370.45 | 2.54 | 2.54 |
| 384.43 | 2.26 | 2.26 |
| 368.48 | 3.09 | 3.09 |
| 384.87 | 3.05 | 3.05 |
| 380.45 | 2.41 | 2.41 |
| 367.42 | 3.14 | 3.14 |
| 380.45 | 2.41 | 2.41 |
| 372.46 | 2.79 | 2.79 |
| 364.45 | 2.71 | 2.71 |
| 393.49 | 3.32 | 3.32 |
| 363.46 | 3.31 | 3.31 |
| 384.48 | 2.93 | 2.93 |
| 397.91 | 3.97 | 3.97 |
| 369.46 | 4.03 | 4.03 |
| 384.87 | 3.05 | 3.05 |
| 413.91 | 3.67 | 3.67 |
| 364.45 | 2.71 | 2.71 |
| 393.49 | 3.32 | 3.32 |
| 364.45 | 2.71 | 2.71 |
| 367.47 | 3.13 | 3.13 |
| 433.43 | 3.90 | 3.90 |
| 380.45 | 2.41 | 2.41 |
| 380.45 | 2.41 | 2.41 |
| 340.42 | 2.53 | 2.53 |
| 379.46 | 3.01 | 3.01 |
| 384.87 | 3.05 | 3.05 |
| 379.46 | 3.01 | 3.01 |
| 396.51 | 3.75 | 3.75 |
| 409.49 | 3.02 | 3.02 |
| 351.41 | 2.66 | 2.66 |
| 413.91 | 3.67 | 3.67 |
| 341.41 | 1.93 | 1.93 |
| 379.46 | 3.01 | 3.01 |
| 374.87 | 3.19 | 3.19 |
| 355.44 | 2.24 | 2.24 |
| 393.49 | 3.32 | 3.32 |
| 394.43 | 2.91 | 2.91 |
| 384.87 | 3.05 | 3.05 |
| 377.49 | 3.62 | 3.62 |
| 380.45 | 2.41 | 2.41 |
| 424.42 | 3.43 | 3.43 |
| 350.42 | 2.40 | 2.40 |
| 300.36 | 1.25 | 1.25 |
| 370.45 | 2.54 | 2.54 |
| 371.44 | 1.94 | 1.94 |
| 393.49 | 3.02 | 3.02 |
| 379.46 | 3.01 | 3.01 |
| 350.42 | 2.40 | 2.40 |
| 351.41 | 1.79 | 1.79 |
| 409.49 | 3.02 | 3.02 |
| 393.49 | 3.32 | 3.32 |
| 413.91 | 3.67 | 3.67 |
| 364.45 | 2.41 | 2.41 |
| 409.49 | 3.02 | 3.02 |
| 364.45 | 2.71 | 2.71 |
| 370.45 | 2.54 | 2.54 |
| 278.35 | 1.24 | 1.24 |
| 351.41 | 1.79 | 1.79 |
| 342.44 | 2.90 | 2.90 |
| 393.49 | 3.32 | 3.32 |
| 341.41 | 1.93 | 1.93 |
| 384.48 | 2.93 | 2.93 |
| 351.41 | 1.79 | 1.79 |
| 380.45 | 2.41 | 2.41 |
| 349.43 | 3.00 | 3.00 |
| 383.88 | 3.66 | 3.66 |
| 364.45 | 2.71 | 2.71 |
| 380.45 | 2.41 | 2.41 |
| 380.44 | 3.28 | 3.28 |
| 370.45 | 2.54 | 2.54 |
| 393.44 | 2.73 | 2.73 |
| 346.47 | 2.80 | 2.80 |
| 428.33 | 3.77 | 3.77 |
| 384.48 | 2.93 | 2.93 |
| 350.42 | 2.40 | 2.40 |
| 413.91 | 3.67 | 3.67 |
| 351.41 | 1.79 | 1.79 |
| 409.49 | 3.02 | 3.02 |
| 380.45 | 2.41 | 2.41 |
| 380.45 | 2.41 | 2.41 |