Basic Information
ID: ALA4407310
Type: Functional
Description: Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric binding affinity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Ovarian cancer G-protein coupled receptor 1(ALA3713916)
Document: ALA4406806
Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric binding affinity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4407310
pKb
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 277.33 | 2.73 | 2.73 |
| 341.80 | 2.88 | 2.88 |
| 325.35 | 2.36 | 2.36 |
| 413.48 | 4.06 | 4.06 |
| 319.37 | 2.94 | 2.94 |
| 351.41 | 2.62 | 2.62 |
| 321.38 | 2.27 | 2.27 |
| 343.34 | 2.50 | 2.50 |
| 321.38 | 2.53 | 2.53 |
| 363.42 | 2.77 | 2.77 |
| 341.80 | 2.88 | 2.88 |
| 335.41 | 2.71 | 2.71 |
| 417.44 | 4.16 | 4.16 |
| 383.88 | 3.70 | 3.70 |
| 337.38 | 2.23 | 2.23 |
| 306.37 | 2.83 | 2.83 |
| 337.38 | 2.23 | 2.23 |
| 375.35 | 3.24 | 3.24 |
| 355.37 | 2.37 | 2.37 |
| 375.35 | 3.24 | 3.24 |
| 341.80 | 2.88 | 2.88 |
| 307.36 | 2.23 | 2.23 |
| 325.35 | 2.36 | 2.36 |
| 321.38 | 2.68 | 2.68 |
| 369.86 | 3.31 | 3.31 |
| 325.35 | 2.36 | 2.36 |
| 319.37 | 2.94 | 2.94 |
| 353.40 | 2.80 | 2.80 |
| 351.41 | 2.62 | 2.62 |
| 325.35 | 2.36 | 2.36 |
| 337.38 | 2.23 | 2.23 |
| 293.33 | 2.36 | 2.36 |
| 320.40 | 2.45 | 2.45 |
| 339.37 | 2.67 | 2.67 |
| 399.45 | 4.02 | 4.02 |
| 321.38 | 2.53 | 2.53 |
| 343.34 | 2.50 | 2.50 |
| 367.43 | 3.19 | 3.19 |
| 445.50 | 4.59 | 4.59 |
| 365.44 | 3.01 | 3.01 |
| 325.35 | 2.36 | 2.36 |
| 365.44 | 3.01 | 3.01 |
| 321.38 | 2.79 | 2.79 |
| 291.36 | 3.04 | 3.04 |
| 321.38 | 2.53 | 2.53 |
| 335.41 | 2.66 | 2.66 |
| 349.44 | 3.05 | 3.05 |
| 306.37 | 2.19 | 2.19 |
| 307.36 | 2.23 | 2.23 |
| 325.35 | 2.36 | 2.36 |
| 447.93 | 4.71 | 4.71 |
| 433.90 | 4.67 | 4.67 |
| 337.38 | 2.23 | 2.23 |
| 341.80 | 2.88 | 2.88 |
| 355.83 | 2.92 | 2.92 |
| 341.80 | 2.88 | 2.88 |
| 325.35 | 2.36 | 2.36 |
| 337.38 | 2.23 | 2.23 |
| 339.37 | 2.41 | 2.41 |
| 335.41 | 3.07 | 3.07 |
| 427.51 | 4.45 | 4.45 |
| 337.38 | 2.23 | 2.23 |
| 431.47 | 4.20 | 4.20 |
| 341.80 | 2.88 | 2.88 |
| 337.38 | 2.23 | 2.23 |
| 375.35 | 3.24 | 3.24 |
| 441.54 | 4.84 | 4.84 |