Assay Report Card

Basic Information

ID: ALA4407310

Type: Functional

Description: Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric binding affinity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4407310

pKb

Total(67)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
277.33	2.73	2.73
341.80	2.88	2.88
325.35	2.36	2.36
413.48	4.06	4.06
319.37	2.94	2.94
351.41	2.62	2.62
321.38	2.27	2.27
343.34	2.50	2.50
321.38	2.53	2.53
363.42	2.77	2.77
341.80	2.88	2.88
335.41	2.71	2.71
417.44	4.16	4.16
383.88	3.70	3.70
337.38	2.23	2.23
306.37	2.83	2.83
337.38	2.23	2.23
375.35	3.24	3.24
355.37	2.37	2.37
375.35	3.24	3.24
341.80	2.88	2.88
307.36	2.23	2.23
325.35	2.36	2.36
321.38	2.68	2.68
369.86	3.31	3.31
325.35	2.36	2.36
319.37	2.94	2.94
353.40	2.80	2.80
351.41	2.62	2.62
325.35	2.36	2.36
337.38	2.23	2.23
293.33	2.36	2.36
320.40	2.45	2.45
339.37	2.67	2.67
399.45	4.02	4.02
321.38	2.53	2.53
343.34	2.50	2.50
367.43	3.19	3.19
445.50	4.59	4.59
365.44	3.01	3.01
325.35	2.36	2.36
365.44	3.01	3.01
321.38	2.79	2.79
291.36	3.04	3.04
321.38	2.53	2.53
335.41	2.66	2.66
349.44	3.05	3.05
306.37	2.19	2.19
307.36	2.23	2.23
325.35	2.36	2.36
447.93	4.71	4.71
433.90	4.67	4.67
337.38	2.23	2.23
341.80	2.88	2.88
355.83	2.92	2.92
341.80	2.88	2.88
325.35	2.36	2.36
337.38	2.23	2.23
339.37	2.41	2.41
335.41	3.07	3.07
427.51	4.45	4.45
337.38	2.23	2.23
431.47	4.20	4.20
341.80	2.88	2.88
337.38	2.23	2.23
375.35	3.24	3.24
441.54	4.84	4.84