Basic Information
ID: ALA4407330
Type: Functional
Description: Positive allosteric modulation of mouse GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring efficacy cooperativity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA4407330
log(activity)
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 341.80 | 2.88 | 2.88 |
| 417.44 | 4.16 | 4.16 |
| 369.86 | 3.31 | 3.31 |
| 349.44 | 3.05 | 3.05 |
| 307.36 | 2.23 | 2.23 |
| 355.83 | 2.92 | 2.92 |