Basic Information
ID: ALA4407331
Type: Functional
Description: Positive allosteric modulation of mouse GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric binding affinity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay
Format: BAO_0000219
Organism: Mus musculus
Target: Ovarian cancer G-protein coupled receptor 1(ALA4523380)
Document: ALA4406806
Positive allosteric modulation of mouse GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric binding affinity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4407331
pKb
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 341.80 | 2.88 | 2.88 |
| 417.44 | 4.16 | 4.16 |
| 369.86 | 3.31 | 3.31 |
| 349.44 | 3.05 | 3.05 |
| 307.36 | 2.23 | 2.23 |
| 355.83 | 2.92 | 2.92 |