Basic Information
ID: ALA4408478
Type: Binding
Description: Inhibition of FASN in human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as disruption of AKT/FASN positive feedback loop by measuring reduction in phosphorylated AKT expression at 50 uM after 48 hrs by Western immunoblot based densitometric assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Target: Fatty acid synthase(ALA4158)
Document: ALA4406830
Inhibition of FASN in human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as disruption of AKT/FASN positive feedback loop by measuring reduction in phosphorylated AKT expression at 50 uM after 48 hrs by Western immunoblot based densitometric assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4408478
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 600.62 | 6.35 | 6.35 |