Inhibition of recombinant Cryptosporidium hominis TS-DHFR expresssed in Escherichia coli PA414 using dUMP and 5,10-methylenetetrahydrofolate as substr...

Basic Information

ID: ALA4409185

Type: Binding

Description: Inhibition of recombinant Cryptosporidium hominis TS-DHFR expresssed in Escherichia coli PA414 using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometry

Format: BAO_0000357

Organism: Cryptosporidium hominis

Target: Bifunctional dihydrofolate reductase-thymidylate synthase(ALA4296761)

Document: ALA4406849

Inhibition of recombinant Cryptosporidium hominis TS-DHFR expresssed in Escherichia coli PA414 using dUMP and 5,10-methylenetetrahydrofolate as substrate by spectrometry: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4409185

IC50

Total(26)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
433.42	1.87	1.87
409.45	1.80	1.80
427.43	1.86	1.86
447.45	2.31	2.31
417.43	2.30	2.30
447.45	2.52	2.52
417.43	2.40	2.40
461.43	2.00	2.00
446.42	1.47	1.47
433.42	2.38	2.38
447.45	2.52	2.52
431.45	2.69	2.69
403.40	2.37	2.37
433.42	2.38	2.38
403.40	2.37	2.37
403.40	2.37	2.37
386.41	3.29	3.29
447.41	2.07	2.07
428.41	2.25	2.25
420.47	3.13	3.13
390.40	2.80	2.80
417.43	2.05	2.05
384.40	2.55	2.55
442.44	2.18	2.18
395.42	1.50	1.50
437.84	3.03	3.03