Basic Information
ID: ALA4409427
Type: Binding
Description: Inhibition of wild type recombinant human C-terminal His8-tagged IDH1 expressed in Escherichia coli BL21 assessed as reduction in NADP consumption using DL-isocitrate as substrate preincubated for 60 mins followed by substrate addition and measured for 60 mins in presence of NADP by diaphorase/resazurin-based fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4409427
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 490.46 | 5.12 | 5.12 |
| 582.97 | 4.32 | 4.32 |
| 486.50 | 4.93 | 4.93 |
| 456.91 | 4.27 | 4.27 |
| 458.88 | 4.06 | 4.06 |
| 492.43 | 4.43 | 4.43 |
| 490.46 | 4.64 | 4.64 |