Assay Report Card

Basic Information

ID: ALA4409428

Type: Binding

Description: Inhibition of recombinant human C-terminal His8-tagged IDH1 R132C mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 60 mins followed by substrate addition and measured for 60 mins in presence of NADPH by diaphorase/resazurin-based fluorescence assay

Organism: Homo sapiens

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
490.465.125.12
582.974.324.32
486.504.934.93
464.504.294.29
520.525.655.65
504.495.205.20
508.505.145.14
456.914.274.27
458.884.064.06
454.463.423.42
490.464.644.64
470.464.444.44
492.434.434.43
494.475.215.21
508.454.784.78
504.495.205.20
436.493.933.93
514.555.715.71
440.453.763.76
524.915.295.29
456.914.274.27
562.555.425.42
490.464.644.64
500.535.325.32
449.453.283.28
504.495.035.03