ID: ALA4409428
Type: Binding
Description: Inhibition of recombinant human C-terminal His8-tagged IDH1 R132C mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 60 mins followed by substrate addition and measured for 60 mins in presence of NADPH by diaphorase/resazurin-based fluorescence assay
Organism: Homo sapiens
Bioactivity
Activity Types for Assay ALA4409428
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
490.46 | 5.12 | 5.12 |
582.97 | 4.32 | 4.32 |
486.50 | 4.93 | 4.93 |
464.50 | 4.29 | 4.29 |
520.52 | 5.65 | 5.65 |
504.49 | 5.20 | 5.20 |
508.50 | 5.14 | 5.14 |
456.91 | 4.27 | 4.27 |
458.88 | 4.06 | 4.06 |
454.46 | 3.42 | 3.42 |
490.46 | 4.64 | 4.64 |
470.46 | 4.44 | 4.44 |
492.43 | 4.43 | 4.43 |
494.47 | 5.21 | 5.21 |
508.45 | 4.78 | 4.78 |
504.49 | 5.20 | 5.20 |
436.49 | 3.93 | 3.93 |
514.55 | 5.71 | 5.71 |
440.45 | 3.76 | 3.76 |
524.91 | 5.29 | 5.29 |
456.91 | 4.27 | 4.27 |
562.55 | 5.42 | 5.42 |
490.46 | 4.64 | 4.64 |
500.53 | 5.32 | 5.32 |
449.45 | 3.28 | 3.28 |
504.49 | 5.03 | 5.03 |