Basic Information
ID: ALA4409429
Type: Binding
Description: Inhibition of recombinant human C-terminal His8-tagged IDH1 R132H mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 60 mins followed by substrate addition measured for 60 mins in presence of NADPH by diaphorase/resazurin-based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4409429
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 490.46 | 5.12 | 5.12 |
| 582.97 | 4.32 | 4.32 |
| 486.50 | 4.93 | 4.93 |
| 464.50 | 4.29 | 4.29 |
| 520.52 | 5.65 | 5.65 |
| 504.49 | 5.20 | 5.20 |
| 508.50 | 5.14 | 5.14 |
| 456.91 | 4.27 | 4.27 |
| 458.88 | 4.06 | 4.06 |
| 454.46 | 3.42 | 3.42 |
| 490.46 | 4.64 | 4.64 |
| 470.46 | 4.44 | 4.44 |
| 492.43 | 4.43 | 4.43 |
| 494.47 | 5.21 | 5.21 |
| 508.45 | 4.78 | 4.78 |
| 504.49 | 5.20 | 5.20 |
| 436.49 | 3.93 | 3.93 |
| 514.55 | 5.71 | 5.71 |
| 440.45 | 3.76 | 3.76 |
| 524.91 | 5.29 | 5.29 |
| 456.91 | 4.27 | 4.27 |
| 562.55 | 5.42 | 5.42 |
| 490.46 | 4.64 | 4.64 |
| 500.53 | 5.32 | 5.32 |
| 449.45 | 3.28 | 3.28 |
| 504.49 | 5.03 | 5.03 |