Inhibition of recombinant human full length N-terminal His6/SUMO-tagged HDAC8 expressed in Escherichia coli BL21 DE3 using Boc-Lys(Ac)-AMC as substrat...

Basic Information

ID: ALA4409769

Type: Binding

Description: Inhibition of recombinant human full length N-terminal His6/SUMO-tagged HDAC8 expressed in Escherichia coli BL21 DE3 using Boc-Lys(Ac)-AMC as substrate incubated for 1 hr by fluorescence based assay

Format: BAO_0000019

Organism: Homo sapiens

Target: Histone deacetylase 8(ALA3192)

Document: ALA4406872

Inhibition of recombinant human full length N-terminal His6/SUMO-tagged HDAC8 expressed in Escherichia coli BL21 DE3 using Boc-Lys(Ac)-AMC as substrate incubated for 1 hr by fluorescence based assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4409769

IC50

Total(45)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
360.25	3.13	3.13
238.31	2.28	2.28
254.77	2.79	2.79
238.31	2.28	2.28
254.77	2.79	2.79
360.24	3.13	3.13
252.34	2.67	2.67
313.25	3.29	3.29
248.38	2.84	2.84
234.35	2.45	2.45
299.22	2.90	2.90
252.34	2.67	2.67
313.24	3.29	3.29
268.79	3.18	3.18
259.36	2.40	2.40
238.31	2.28	2.28
254.77	2.79	2.79
299.22	2.90	2.90
254.77	2.79	2.79
250.35	2.15	2.15
268.79	3.18	3.18
218.28	1.82	1.82
299.22	2.90	2.90
250.35	2.15	2.15
346.22	2.74	2.74
252.34	2.67	2.67
248.38	2.84	2.84
220.32	2.14	2.14
268.79	3.18	3.18
268.79	3.18	3.18
248.38	2.84	2.84
263.39	2.21	2.21
248.38	2.84	2.84
252.34	2.67	2.67
277.42	2.60	2.60
234.35	2.45	2.45
302.35	3.55	3.55
317.21	3.04	3.04
218.28	2.36	2.36
346.22	2.74	2.74
245.33	2.01	2.01
234.35	2.45	2.45
313.25	3.29	3.29
234.35	2.53	2.53
234.35	2.45	2.45