Basic Information
ID: ALA4410623
Type: Functional
Description: Antimalarial activity against pyrimethamine-resistant Plasmodium falciparum V1/S expressing Dihydrofolate reductase N51I/C59R/S108N/I164L mutant infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 18 to 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method
Organism: Plasmodium falciparum
Strain: V1/S
Activity Charts
Bioactivity
Activity Types for Assay ALA4410623
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 248.72 | 2.52 | 2.52 |