Basic Information
ID: ALA4410893
Type: Binding
Description: Allosteric inhibition of human N-terminal GST-tagged EGFR double T790M/L858R mutant (696 to 1022 residues) expressed in Sf21 insect cells assessed as change in inhibition rate in presence of 1 to 1000 uM ATP by HTRF assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: Sf21
Target: Epidermal growth factor receptor erbB1(ALA203)
Document: ALA4406912
Allosteric inhibition of human N-terminal GST-tagged EGFR double T790M/L858R mutant (696 to 1022 residues) expressed in Sf21 insect cells assessed as change in inhibition rate in presence of 1 to 1000 uM ATP by HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4410893
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 494.57 | 5.93 | 5.93 |
| 508.60 | 6.27 | 6.27 |