Basic Information
ID: ALA4411171
Type: Binding
Description: Inhibition of 0.05 nM DOT1L (2 to 416 residues) (unknown origin) using biotinylated nucleosome as substrate and [3H]SAM as co-factor preincubated for 30 mins followed by substrate and cofactor addition and measured after 180 mins by scintillation proximity assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Histone-lysine N-methyltransferase, H3 lysine-79 specific(ALA1795117)
Document: ALA4406923
Inhibition of 0.05 nM DOT1L (2 to 416 residues) (unknown origin) using biotinylated nucleosome as substrate and [3H]SAM as co-factor preincubated for 30 mins followed by substrate and cofactor addition and measured after 180 mins by scintillation proximity assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4411171
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 592.97 | 3.42 | 3.42 |
| 661.09 | 4.01 | 4.01 |
| 526.98 | 4.11 | 4.11 |
| 562.99 | 4.56 | 4.56 |
| 607.00 | 4.61 | 4.61 |