Basic Information
ID: ALA4411582
Type: Binding
Description: Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN-alpha addition and measured measured after 15 mins by FACS assay
Format: BAO_0000219
Organism: Homo sapiens
Target: JAK1/TYK2(ALA3301391)
Document: ALA4411260
Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN-alpha addition and measured measured after 15 mins by FACS assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4411582
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.38 | 1.54 | 1.54 |
| 453.52 | 2.40 | 2.40 |
| 439.50 | 2.09 | 2.09 |
| 389.41 | 1.79 | 1.79 |
| 389.41 | 1.79 | 1.79 |
| 356.43 | 1.34 | 1.34 |
| 367.42 | 0.84 | 0.84 |
| 410.40 | 1.88 | 1.88 |
| 401.45 | 1.14 | 1.14 |
| 353.43 | 1.54 | 1.54 |
| 371.42 | 1.68 | 1.68 |