Basic Information
ID: ALA4412443
Type: ADME
Description: Time-dependant irreversible inhibition of CYP2D6 in human liver microsomes at 1 mM using dextromethorphan as substrate preincubated for 5 to 30 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Cytochrome P450 2D6(ALA289)
Document: ALA4411287
Time-dependant irreversible inhibition of CYP2D6 in human liver microsomes at 1 mM using dextromethorphan as substrate preincubated for 5 to 30 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4412443
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 501.51 | 7.01 | 7.01 |