Basic Information
ID: ALA4413815
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes assessed as reduction in midazolam 1-hydroxylase activity at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis relative to control
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4413815
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.01 | 5.06 | 5.06 |
| 529.55 | 5.65 | 5.65 |
| 527.58 | 6.26 | 6.26 |
| 485.50 | 5.14 | 5.14 |
| 529.55 | 5.65 | 5.65 |
| 499.53 | 5.48 | 5.48 |
| 592.45 | 6.71 | 6.71 |
| 592.45 | 6.71 | 6.71 |
| 513.55 | 5.87 | 5.87 |
| 550.37 | 5.59 | 5.59 |