Basic Information
ID: ALA4413915
Type: Binding
Description: Inhibition of recombinant human N-terminal GST/His6-fused FLT3 ITD mutant (R571 to S993 residues) expressed in Sf9 insect cells assessed as residual activity using ULightTM-TK peptide as substrate incubated for 90 mins under dark condition by FRET assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: Sf9
Target: Tyrosine-protein kinase receptor FLT3(ALA1974)
Document: ALA4411324
Inhibition of recombinant human N-terminal GST/His6-fused FLT3 ITD mutant (R571 to S993 residues) expressed in Sf9 insect cells assessed as residual activity using ULightTM-TK peptide as substrate incubated for 90 mins under dark condition by FRET assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4413915
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 517.44 | 4.56 | 4.56 |
| 499.60 | 3.81 | 3.81 |
| 517.61 | 2.68 | 2.68 |
| 475.57 | 2.91 | 2.91 |
| 448.59 | 4.04 | 4.04 |
| 503.45 | 5.04 | 5.04 |
| 517.61 | 2.68 | 2.68 |
| 493.55 | 3.17 | 3.17 |
| 443.57 | 4.48 | 4.48 |
| 459.58 | 3.46 | 3.46 |
| 478.57 | 3.27 | 3.27 |
| 460.56 | 3.32 | 3.32 |
| 434.57 | 3.73 | 3.73 |
| 464.59 | 3.74 | 3.74 |
| 438.51 | 3.24 | 3.24 |
| 448.55 | 2.57 | 2.57 |
| 469.01 | 4.38 | 4.38 |
| 448.55 | 2.57 | 2.57 |
| 517.44 | 4.56 | 4.56 |
| 516.55 | 4.28 | 4.28 |
| 475.57 | 2.91 | 2.91 |
| 331.44 | 1.90 | 1.90 |
| 408.51 | 4.33 | 4.33 |
| 459.58 | 3.46 | 3.46 |
| 433.54 | 3.21 | 3.21 |
| 443.57 | 4.48 | 4.48 |
| 458.59 | 4.22 | 4.22 |
| 482.99 | 3.91 | 3.91 |
| 472.61 | 4.56 | 4.56 |
| 448.55 | 2.57 | 2.57 |
| 468.58 | 4.52 | 4.52 |
| 446.58 | 3.80 | 3.80 |
| 493.63 | 5.64 | 5.64 |
| 432.55 | 3.41 | 3.41 |
| 458.59 | 4.22 | 4.22 |
| 444.56 | 3.88 | 3.88 |
| 433.54 | 3.21 | 3.21 |
| 466.54 | 3.40 | 3.40 |
| 408.53 | 2.91 | 2.91 |
| 460.60 | 4.14 | 4.14 |
| 448.55 | 3.26 | 3.26 |
| 462.58 | 3.57 | 3.57 |
| 445.54 | 4.31 | 4.31 |
| 493.55 | 3.17 | 3.17 |
| 482.99 | 3.91 | 3.91 |
| 451.55 | 2.08 | 2.08 |
| 418.52 | 3.36 | 3.36 |
| 447.56 | 4.22 | 4.22 |
| 485.61 | 4.28 | 4.28 |
| 445.59 | 5.38 | 5.38 |
| 482.99 | 3.91 | 3.91 |