Basic Information
ID: ALA4413935
Type: Binding
Description: Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of nicotine-induced currents at 50 uM pretreated for 5 mins followed by nicotine addition after 4 to 5 days at -60 mV holding potential by patch clamp assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Target: Neuronal acetylcholine receptor; alpha4/beta2(ALA1907589)
Document: ALA4411326
Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of nicotine-induced currents at 50 uM pretreated for 5 mins followed by nicotine addition after 4 to 5 days at -60 mV holding potential by patch clamp assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4413935
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 202.30 | 2.18 | 2.18 |
| 250.77 | 3.18 | 3.18 |
| 188.27 | 1.92 | 1.92 |
| 222.72 | 2.58 | 2.58 |