Basic Information
ID: ALA4414023
Type: Binding
Description: Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincubated for 30 to 60 mins followed by substrate addition and measured after 30 mins bpV-based fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4414023
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 352.27 | 3.35 | 3.35 |
| 382.30 | 2.65 | 2.65 |
| 451.00 | 2.20 | 2.20 |
| 441.48 | 2.67 | 2.67 |
| 454.52 | 3.28 | 3.28 |
| 407.31 | 2.95 | 2.95 |
| 470.52 | 2.26 | 2.26 |
| 311.20 | 4.00 | 4.00 |
| 399.44 | 2.90 | 2.90 |
| 455.51 | 2.68 | 2.68 |
| 428.39 | 3.39 | 3.39 |
| 486.54 | 3.22 | 3.22 |
| 469.53 | 2.87 | 2.87 |
| 470.43 | 3.15 | 3.15 |
| 477.03 | 2.77 | 2.77 |
| 468.55 | 3.27 | 3.27 |