Basic Information
ID: ALA4414043
Type: Functional
Description: In vivo inhibition of SHP2 in human Detroit 562 cells xenografted in NU/NU mouse assessed as reduction in DUSP6 mRNA levels at 20 to 80 mg/kg, po administered BID and measured after 3 hrs by qPCR analysis
Format: BAO_0000218
Organism: Mus musculus
Target: Mus musculus(ALA375)
Document: ALA4411331
In vivo inhibition of SHP2 in human Detroit 562 cells xenografted in NU/NU mouse assessed as reduction in DUSP6 mRNA levels at 20 to 80 mg/kg, po administered BID and measured after 3 hrs by qPCR analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4414043
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 470.52 | 2.26 | 2.26 |