Basic Information
ID: ALA4414743
Type: Binding
Description: Inhibition of human 5-LO transfected in HEK293 cells coexpressing FLAP assessed as reduction in leukotriene formation at 1 uM using arachidonic acid as substrate preincubated for 5 mins followed by calcium ionophore A23187/arachidonic acid addition and measured after 15 mins by RP-HPLC analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Arachidonate 5-lipoxygenase(ALA215)
Document: ALA4414547
Inhibition of human 5-LO transfected in HEK293 cells coexpressing FLAP assessed as reduction in leukotriene formation at 1 uM using arachidonic acid as substrate preincubated for 5 mins followed by calcium ionophore A23187/arachidonic acid addition and measured after 15 mins by RP-HPLC analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4414743
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 236.30 | 2.73 | 2.73 |
| 284.31 | 2.90 | 2.90 |
| 298.34 | 3.29 | 3.29 |
| 298.34 | 3.29 | 3.29 |
| 258.27 | 2.50 | 2.50 |
| 298.34 | 3.29 | 3.29 |
| 268.31 | 3.31 | 3.31 |
| 284.31 | 2.90 | 2.90 |