Basic Information
ID: ALA4414793
Type: Binding
Description: Inhibition of TYK2 JH2 domain in human whole blood assessed as inhibition of IFNalpha-induced STAT5 phosphorylation preincubated for 1 hr followed by IFNalpha stimulation and measured after 15 mins by fluorescence assay
Organism: Homo sapiens
Tissue: Blood
Activity Charts
Bioactivity
Activity Types for Assay ALA4414793
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 388.45 | 1.94 | 1.94 |
| 401.47 | 2.12 | 2.12 |
| 418.47 | 2.87 | 2.87 |
| 392.46 | 1.33 | 1.33 |
| 427.49 | 2.74 | 2.74 |
| 412.48 | 2.43 | 2.43 |
| 429.48 | 3.26 | 3.26 |
| 367.38 | 3.47 | 3.47 |
| 383.45 | 4.18 | 4.18 |
| 482.57 | 2.56 | 2.56 |
| 403.36 | 3.75 | 3.75 |
| 415.45 | 2.87 | 2.87 |
| 401.42 | 2.61 | 2.61 |
| 390.47 | 2.18 | 2.18 |
| 380.38 | 2.56 | 2.56 |
| 390.47 | 2.33 | 2.33 |
| 397.46 | 2.73 | 2.73 |
| 411.49 | 3.04 | 3.04 |
| 419.46 | 2.26 | 2.26 |
| 337.36 | 3.46 | 3.46 |