Basic Information
ID: ALA4415470
Type: ADME
Description: Time-dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam or testosterone as substrate preincubated up to 30 mins followed by NADPH generating system addition and measured after 10 mins
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4415470
TDI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 541.70 | 4.18 | 4.18 |
| 415.54 | 4.67 | 4.67 |
| 499.62 | 2.96 | 2.96 |
| 527.67 | 3.74 | 3.74 |
| 387.49 | 3.88 | 3.88 |
| 373.46 | 3.58 | 3.58 |