Basic Information
ID: ALA4416106
Type: Binding
Description: Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 120 mins by kinase-Glo plus luminescent kinase assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Epidermal growth factor receptor erbB1(ALA203)
Document: ALA4414600
Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 120 mins by kinase-Glo plus luminescent kinase assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4416106
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 446.91 | 4.28 | 4.28 |
| 485.95 | 4.39 | 4.39 |
| 476.54 | 5.83 | 5.83 |
| 407.47 | 5.70 | 5.70 |
| 476.54 | 5.83 | 5.83 |
| 400.44 | 4.16 | 4.16 |
| 548.60 | 5.76 | 5.76 |
| 512.59 | 5.59 | 5.59 |
| 401.43 | 3.55 | 3.55 |
| 430.53 | 4.94 | 4.94 |
| 490.56 | 6.22 | 6.22 |
| 414.47 | 4.47 | 4.47 |
| 533.63 | 5.76 | 5.76 |
| 488.55 | 5.66 | 5.66 |
| 577.69 | 5.51 | 5.51 |
| 561.69 | 6.54 | 6.54 |
| 450.95 | 5.28 | 5.28 |
| 460.54 | 6.85 | 6.85 |
| 533.63 | 5.76 | 5.76 |
| 552.63 | 7.35 | 7.35 |
| 532.64 | 7.24 | 7.24 |
| 492.60 | 6.30 | 6.30 |
| 416.51 | 4.63 | 4.63 |
| 506.56 | 5.84 | 5.84 |
| 520.55 | 5.28 | 5.28 |
| 575.67 | 5.53 | 5.53 |