Basic Information
ID: ALA4416381
Type: Functional
Description: Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of EC80 CP55,940-induced calcium mobilization at 10 uM preincubated for 15 mins followed by CP55,490 addition measured at 1 sec interval for 90 secs by calcium-5 dye based FLIPR assay relative to CP55,940
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: Cannabinoid CB2 receptor(ALA253)
Document: ALA4414612
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of EC80 CP55,940-induced calcium mobilization at 10 uM preincubated for 15 mins followed by CP55,490 addition measured at 1 sec interval for 90 secs by calcium-5 dye based FLIPR assay relative to CP55,940: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4416381
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 392.89 | 5.65 | 5.65 |
| 342.85 | 6.02 | 6.02 |
| 358.85 | 5.72 | 5.72 |
| 323.78 | 5.05 | 5.05 |
| 286.76 | 4.02 | 4.02 |
| 371.89 | 5.78 | 5.78 |
| 397.71 | 7.02 | 7.02 |
| 346.81 | 5.85 | 5.85 |
| 323.78 | 5.05 | 5.05 |
| 363.27 | 6.37 | 6.37 |
| 286.76 | 4.02 | 4.02 |
| 370.86 | 5.92 | 5.92 |
| 397.71 | 7.02 | 7.02 |
| 329.83 | 4.13 | 4.13 |
| 358.85 | 5.72 | 5.72 |
| 328.82 | 5.71 | 5.71 |
| 328.82 | 5.71 | 5.71 |
| 323.78 | 5.05 | 5.05 |
| 422.92 | 5.65 | 5.65 |
| 328.82 | 5.71 | 5.71 |
| 363.27 | 6.37 | 6.37 |
| 406.92 | 5.12 | 5.12 |
| 363.27 | 6.37 | 6.37 |
| 346.81 | 5.85 | 5.85 |
| 386.86 | 5.50 | 5.50 |
| 323.78 | 5.05 | 5.05 |
| 329.81 | 5.11 | 5.11 |
| 329.81 | 5.11 | 5.11 |
| 358.85 | 5.72 | 5.72 |
| 364.80 | 5.99 | 5.99 |
| 329.81 | 5.11 | 5.11 |