Basic Information
ID: ALA4416382
Type: Functional
Description: Allosteric modulator activity at human CB1 receptor expressed in HEK293 cells assessed as suppression of 100 nM CP55,940-induced reduction in forskolin-stimulated cAMP production pre-incubated for 25 mins before forskolin and CP55,940 addition and measured after 22 mins by BRET CAMYEL cAMP assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Cannabinoid CB1 receptor(ALA218)
Document: ALA4414612
Allosteric modulator activity at human CB1 receptor expressed in HEK293 cells assessed as suppression of 100 nM CP55,940-induced reduction in forskolin-stimulated cAMP production pre-incubated for 25 mins before forskolin and CP55,940 addition and measured after 22 mins by BRET CAMYEL cAMP assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4416382
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 392.89 | 5.65 | 5.65 |
| 342.85 | 6.02 | 6.02 |
| 358.85 | 5.72 | 5.72 |
| 371.89 | 5.78 | 5.78 |
| 397.71 | 7.02 | 7.02 |
| 346.81 | 5.85 | 5.85 |
| 363.27 | 6.37 | 6.37 |
| 370.86 | 5.92 | 5.92 |
| 397.71 | 7.02 | 7.02 |
| 358.85 | 5.72 | 5.72 |
| 328.82 | 5.71 | 5.71 |
| 363.27 | 6.37 | 6.37 |
| 406.92 | 5.12 | 5.12 |
| 363.27 | 6.37 | 6.37 |
| 346.81 | 5.85 | 5.85 |
| 386.86 | 5.50 | 5.50 |
| 329.81 | 5.11 | 5.11 |
| 329.81 | 5.11 | 5.11 |
| 358.85 | 5.72 | 5.72 |
| 364.80 | 5.99 | 5.99 |