Basic Information
ID: ALA4416474
Type: ADME
Description: Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate measured after 3 to 20 hrs by HTRF assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Tyrosine-protein kinase JAK2(ALA2971)
Document: ALA4414617
Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using PolyGT-Biotin as substrate measured after 3 to 20 hrs by HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4416474
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 420.38 | 3.11 | 3.11 |
| 419.45 | 1.78 | 1.78 |
| 474.53 | 1.46 | 1.46 |
| 435.44 | 0.48 | 0.48 |
| 432.49 | 1.69 | 1.69 |
| 428.84 | 1.28 | 1.28 |
| 435.44 | 0.48 | 0.48 |
| 420.38 | 3.08 | 3.08 |
| 374.38 | 3.18 | 3.18 |
| 367.34 | 1.69 | 1.69 |
| 401.79 | 2.35 | 2.35 |
| 365.40 | 2.20 | 2.20 |
| 354.35 | 1.92 | 1.92 |
| 368.37 | 2.05 | 2.05 |
| 405.42 | 1.12 | 1.12 |
| 394.35 | 2.11 | 2.11 |
| 416.42 | 2.99 | 2.99 |
| 361.37 | 1.66 | 1.66 |
| 375.39 | 1.67 | 1.67 |
| 428.81 | 2.72 | 2.72 |
| 385.33 | 1.83 | 1.83 |
| 424.39 | 2.07 | 2.07 |
| 399.84 | 2.85 | 2.85 |
| 412.36 | 2.20 | 2.20 |
| 433.47 | 1.90 | 1.90 |
| 393.36 | 2.72 | 2.72 |
| 408.39 | 2.37 | 2.37 |
| 382.40 | 2.44 | 2.44 |
| 394.40 | 0.63 | 0.63 |
| 390.40 | 1.97 | 1.97 |
| 394.37 | 2.06 | 2.06 |
| 398.40 | 1.39 | 1.39 |
| 374.38 | 3.18 | 3.18 |
| 382.40 | 2.70 | 2.70 |
| 394.40 | 0.63 | 0.63 |