Basic Information
ID: ALA4416608
Type: Binding
Description: Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA
Format: BAO_0000219
Organism: Mus musculus
Target: NACHT, LRR and PYD domains-containing protein 3(ALA3779755)
Document: ALA4414625
Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4416608
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 532.09 | 4.38 | 4.38 |
| 573.18 | 5.70 | 5.70 |
| 540.09 | 4.25 | 4.25 |
| 434.99 | 3.71 | 3.71 |
| 511.04 | 4.07 | 4.07 |
| 578.13 | 5.34 | 5.34 |
| 446.96 | 3.02 | 3.02 |
| 527.05 | 3.72 | 3.72 |
| 529.06 | 3.58 | 3.58 |
| 517.07 | 4.14 | 4.14 |
| 559.15 | 5.31 | 5.31 |
| 475.01 | 3.80 | 3.80 |
| 432.97 | 3.49 | 3.49 |
| 515.03 | 4.52 | 4.52 |
| 589.58 | 5.02 | 5.02 |
| 569.12 | 4.86 | 4.86 |
| 516.02 | 3.04 | 3.04 |
| 540.09 | 4.25 | 4.25 |
| 553.12 | 5.24 | 5.24 |
| 559.15 | 5.30 | 5.30 |
| 448.97 | 3.24 | 3.24 |
| 528.67 | 4.40 | 4.40 |
| 545.13 | 4.92 | 4.92 |
| 531.10 | 4.99 | 4.99 |
| 539.10 | 4.85 | 4.85 |
| 491.05 | 4.41 | 4.41 |
| 533.08 | 3.78 | 3.78 |