Basic Information
ID: ALA4416627
Type: Unassigned
Description: Ratio of IC50 for inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA to drug level in C57BL/6 mouse brain at 20 mg/kg, po measured after 4 hrs by LC-MS/MS analysis
Format: BAO_0000218
Organism: Mus musculus
Target: Unchecked(ALA612545)
Document: ALA4414625
Ratio of IC50 for inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA to drug level in C57BL/6 mouse brain at 20 mg/kg, po measured after 4 hrs by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4416627
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 545.13 | 4.92 | 4.92 |