Basic Information
ID: ALA4416900
Type: ADME
Description: Inhibition of recombinant human CYP2J2 expressed in baculovirus infected insect cells co-expressing NADPH-CYP reductase and cytochrome b5 assessed as reduction in CYP2J2-mediated EPA epoxidation by measuring sum of EEQ and DiHETEs level at 1 to 50 uM using EPA as substrate preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LCMS/MS analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4416900
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 471.69 | 6.45 | 6.45 |
| 645.32 | 6.94 | 6.94 |
| 556.77 | 7.05 | 7.05 |
| 354.49 | 3.17 | 3.17 |
| 378.52 | 2.45 | 2.45 |
| 356.46 | 2.02 | 2.02 |