Basic Information
ID: ALA4417044
Type: Binding
Description: Binding affinity to MetAP2 in human A549 cells harboring siRNA pool at >=30 nM preincubated 4 hrs prior to compound washout and cell lysis followed by 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 probe addition and measured by fluorescence correlation spectroscopic method relative to control
Organism: Homo sapiens
Cell type: A549
Activity Charts
Bioactivity
Activity Types for Assay ALA4417044
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 402.81 | 2.14 | 2.14 |
| 386.36 | 1.63 | 1.63 |
| 385.37 | 2.23 | 2.23 |
| 431.85 | 2.15 | 2.15 |