Basic Information
ID: ALA4417106
Type: Binding
Description: Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged GGPPS expressed in Escherichia coli BL21 (DE3) using FPP and [14C] IPP as substrate preincubated for 15 mins with FPP followed by [14C] IPP addition and further incubated for 20 mins by scintillation counting method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4417106
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 332.44 | 4.32 | 4.32 |
| 330.42 | 4.29 | 4.29 |
| 314.43 | 4.44 | 4.44 |
| 346.47 | 4.40 | 4.40 |
| 290.11 | -1.12 | -1.12 |
| 413.52 | 4.32 | 4.32 |
| 416.56 | 3.55 | 3.55 |
| 422.57 | 4.94 | 4.94 |
| 344.41 | 3.41 | 3.41 |
| 374.48 | 3.42 | 3.42 |
| 454.63 | 6.70 | 6.70 |
| 390.52 | 4.94 | 4.94 |
| 371.48 | 4.25 | 4.25 |
| 514.46 | 5.95 | 5.95 |
| 421.58 | 5.55 | 5.55 |
| 430.54 | 4.84 | 4.84 |
| 427.63 | 6.07 | 6.07 |
| 450.58 | 5.92 | 5.92 |
| 360.45 | 4.04 | 4.04 |
| 513.64 | 5.89 | 5.89 |
| 328.41 | 3.16 | 3.16 |
| 358.43 | 2.98 | 2.98 |
| 402.58 | 3.91 | 3.91 |
| 511.62 | 4.72 | 4.72 |
| 439.60 | 4.63 | 4.63 |
| 422.59 | 4.63 | 4.63 |
| 345.48 | 3.98 | 3.98 |
| 375.51 | 3.34 | 3.34 |
| 314.43 | 3.63 | 3.63 |
| 478.97 | 4.70 | 4.70 |
| 499.65 | 6.25 | 6.25 |
| 523.42 | 4.86 | 4.86 |
| 525.44 | 6.73 | 6.73 |
| 373.49 | 3.89 | 3.89 |
| 412.49 | 4.51 | 4.51 |
| 507.65 | 4.23 | 4.23 |
| 410.47 | 3.34 | 3.34 |
| 346.47 | 3.22 | 3.22 |
| 384.48 | 4.61 | 4.61 |
| 388.50 | 3.81 | 3.81 |
| 420.57 | 3.50 | 3.50 |
| 434.64 | 6.44 | 6.44 |
| 376.49 | 4.55 | 4.55 |
| 502.65 | 4.79 | 4.79 |
| 316.44 | 4.76 | 4.76 |
| 523.43 | 5.57 | 5.57 |
| 429.56 | 4.26 | 4.26 |
| 342.39 | 2.34 | 2.34 |
| 370.49 | 4.97 | 4.97 |
| 474.71 | ||
| 344.45 | 4.28 | 4.28 |
| 374.48 | 3.43 | 3.43 |
| 318.46 | 4.22 | 4.22 |
| 457.57 | 6.20 | 6.20 |
| 511.46 | 7.09 | 7.09 |
| 382.46 | 3.45 | 3.45 |
| 413.56 | 4.72 | 4.72 |