Basic Information
ID: ALA4417725
Type: Binding
Description: Inhibition of P-gp in human K562/R7 cells assessed as potentiation of 1 uM doxorubicin-induced cytotoxicity by measuring [3H]thymidine incorporation at 1 uM pre-incubated for 24 hrs before [3H]thymidine addition and measured after 24 hrs relative to untreated control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: K562/R7
Target: P-glycoprotein 1(ALA4302)
Document: ALA4417622
Inhibition of P-gp in human K562/R7 cells assessed as potentiation of 1 uM doxorubicin-induced cytotoxicity by measuring [3H]thymidine incorporation at 1 uM pre-incubated for 24 hrs before [3H]thymidine addition and measured after 24 hrs relative to untreated control: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4417725
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 314.47 | 4.72 | 4.72 |
| 1202.63 | ||
| 414.59 | 5.39 | 5.39 |
| 416.60 | 5.33 | 5.33 |
| 556.70 | 6.47 | 6.47 |
| 536.71 | 6.16 | 6.16 |
| 536.71 | 6.16 | 6.16 |
| 516.72 | 5.99 | 5.99 |
| 414.59 | 5.39 | 5.39 |
| 542.72 | 7.30 | 7.30 |
| 628.81 | 7.47 | 7.47 |
| 536.71 | 6.16 | 6.16 |
| 542.72 | 7.30 | 7.30 |
| 414.59 | 5.39 | 5.39 |
| 516.72 | 5.99 | 5.99 |
| 414.59 | 5.25 | 5.25 |
| 536.71 | 6.16 | 6.16 |
| 556.70 | 6.47 | 6.47 |