Basic Information
ID: ALA4417815
Type: Binding
Description: Inhibition of full-length recombinant human CYP46A1 assessed as cholesterol hydroxylation at 43 uM using cholesterol as substrate in presence of NADPH cytochrome P450 oxidoreductase by gas chromatography-mass spectrometry (Rvb = 100%)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4417815
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 172.21 | -0.08 | -0.08 |
| 180.16 | 1.31 | 1.31 |
| 252.35 | 0.60 | 0.60 |
| 153.18 | 0.60 | 0.60 |
| 369.37 | 3.52 | 3.52 |
| 111.15 | -0.09 | -0.09 |
| 149.24 | 1.84 | 1.84 |
| 314.41 | 1.46 | 1.46 |
| 344.85 | 5.38 | 5.38 |
| 308.84 | 3.45 | 3.45 |
| 349.32 | 2.18 | 2.18 |
| 331.47 | 1.32 | 1.32 |
| 272.39 | 3.61 | 3.61 |
| 296.15 | 4.36 | 4.36 |
| 337.46 | -0.77 | -0.77 |
| 181.19 | 0.35 | 0.35 |
| 165.19 | 0.64 | 0.64 |
| 187.29 | 2.18 | 2.18 |
| 286.46 | 5.51 | 5.51 |
| 197.19 | 0.05 | 0.05 |
| 248.31 | 1.68 | 1.68 |
| 288.43 | 3.88 | 3.88 |
| 386.66 | 7.39 | 7.39 |
| 133.19 | 1.50 | 1.50 |
| 247.28 | 0.53 | 0.53 |
| 324.42 | 3.17 | 3.17 |
| 288.43 | 3.88 | 3.88 |
| 316.49 | 4.52 | 4.52 |
| 292.45 | 2.80 | 2.80 |
| 17.03 | 0.16 | 0.16 |
| 396.55 | 4.34 | 4.34 |
| 466.73 | 7.22 | 7.22 |
| 178.62 | 2.73 | 2.73 |
| 400.65 | 6.57 | 6.57 |
| 352.45 | 3.09 | 3.09 |
| 374.43 | 3.09 | 3.09 |
| 368.50 | 3.71 | 3.71 |
| 390.48 | 3.71 | 3.71 |
| 488.71 | 7.22 | 7.22 |
| 502.69 | 6.39 | 6.39 |