Assay Report Card

Basic Information

ID: ALA4418408

Type: Binding

Description: Inhibition of untagged human USP30 catalytic domain (57 to 517 residues) expressed in Escherichia coli using TAMRA labeled ubiquitin peptide as substrate preincubated for 30 min followed by substrate addition and measured after 2 hrs by fluorescence polarization assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4418408

IC50

Total(273)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
328.35	1.21	1.21
352.40	1.82	1.82
356.43	0.43	0.43
283.29	1.02	1.02
296.33	0.77	0.77
350.36	1.82	1.82
291.35	2.64	2.64
288.36	0.47	0.47
338.37	1.51	1.51
325.37	1.38	1.38
407.47	1.88	1.88
348.83	1.71	1.71
283.29	1.02	1.02
382.86	2.46	2.46
307.36	1.70	1.70
340.81	3.03	3.03
335.37	1.25	1.25
395.44	2.01	2.01
331.33	1.65	1.65
309.34	2.59	2.59
374.45	2.72	2.72
344.78	2.83	2.83
320.40	2.95	2.95
284.32	1.35	1.35
326.79	2.69	2.69
366.40	2.00	2.00
334.42	3.30	3.30
349.40	1.33	1.33
304.78	2.00	2.00
364.41	2.46	2.46
305.38	3.03	3.03
367.39	1.64	1.64
379.32	2.59	2.59
308.34	1.97	1.97
324.39	2.11	2.11
304.78	2.00	2.00
324.36	2.56	2.56
363.40	2.66	2.66
284.36	1.69	1.69
312.40	2.34	2.34
282.31	0.76	0.76
296.33	0.77	0.77
335.37	1.25	1.25
327.36	1.85	1.85
346.39	1.99	1.99
332.82	2.75	2.75
300.36	1.11	1.11
334.38	1.85	1.85
296.37	1.69	1.69
348.41	1.86	1.86
347.42	3.08	3.08
364.38	2.06	2.06
379.87	2.25	2.25
322.37	3.16	3.16
333.40	1.89	1.89
331.33	1.65	1.65
293.33	1.43	1.43
326.34	1.64	1.64
310.33	2.17	2.17
278.74	2.36	2.36
363.43	1.67	1.67
356.36	1.65	1.65
300.36	1.36	1.36
331.33	1.65	1.65
354.39	2.25	2.25
338.38	0.33	0.33
356.35	2.74	2.74
376.34	2.15	2.15
312.40	2.34	2.34
339.42	2.61	2.61
334.38	1.85	1.85
313.34	1.51	1.51
292.34	2.03	2.03
362.44	2.62	2.62
313.34	1.51	1.51
367.31	2.52	2.52
342.40	0.07	0.07
321.38	2.65	2.65
348.41	1.86	1.86
292.34	2.03	2.03
282.35	1.66	1.66
327.43	1.46	1.46
384.39	2.66	2.66
348.41	2.16	2.16
360.42	2.33	2.33
356.39	2.16	2.16
335.37	1.02	1.02
348.82	1.72	1.72
255.28	0.85	0.85
348.41	1.81	1.81
335.37	1.02	1.02
350.30	2.65	2.65
404.47	3.00	3.00
311.35	1.37	1.37
310.36	1.23	1.23
313.34	1.51	1.51
341.39	2.24	2.24
313.28	2.12	2.12
281.32	1.16	1.16
293.33	1.43	1.43
297.32	1.33	1.33
298.37	2.10	2.10
372.43	0.65	0.65
336.40	2.35	2.35
283.29	1.02	1.02
281.32	1.36	1.36
353.45	3.00	3.00
317.39	2.98	2.98
347.42	3.08	3.08
283.29	1.02	1.02
270.34	1.35	1.35
342.40	3.19	3.19
336.40	3.50	3.50
342.30	2.86	2.86
316.75	2.28	2.28
366.40	2.52	2.52
308.74	2.50	2.50
292.34	2.03	2.03
284.36	1.18	1.18
356.39	2.16	2.16
298.27	2.38	2.38
292.34	2.03	2.03
284.36	1.74	1.74
318.28	1.90	1.90
297.32	0.16	0.16
326.33	1.64	1.64
331.33	1.65	1.65
376.46	2.68	2.68
351.39	2.03	2.03
325.80	3.29	3.29
318.35	0.95	0.95
298.35	0.71	0.71
320.34	1.85	1.85
292.34	2.03	2.03
309.37	1.79	1.79
305.38	2.57	2.57
335.37	1.02	1.02
358.42	1.58	1.58
307.36	1.50	1.50
333.40	2.77	2.77
376.46	2.15	2.15
311.35	1.37	1.37
306.37	3.03	3.03
312.40	2.34	2.34
334.38	1.67	1.67
293.33	1.43	1.43
339.40	1.34	1.34
326.32	3.11	3.11
342.30	2.86	2.86
323.40	2.09	2.09
310.33	2.17	2.17
311.32	1.57	1.57
335.41	2.00	2.00
320.40	3.37	3.37
349.37	2.43	2.43
301.35	0.20	0.20
327.36	1.99	1.99
350.36	1.82	1.82
346.41	1.72	1.72
310.36	2.24	2.24
325.35	1.88	1.88
279.73	1.75	1.75
341.42	1.32	1.32
295.35	1.37	1.37
357.39	1.62	1.62
367.39	1.47	1.47
349.40	1.59	1.59
348.41	2.47	2.47
286.34	1.01	1.01
336.40	3.55	3.55
312.37	1.36	1.36
349.39	2.72	2.72
305.38	2.98	2.98
346.41	1.58	1.58
339.37	2.18	2.18
312.30	2.72	2.72
313.34	1.60	1.60
312.30	2.72	2.72
270.34	1.66	1.66
307.35	2.76	2.76
347.39	1.12	1.12
298.39	2.08	2.08
317.30	1.86	1.86
349.40	1.36	1.36
313.34	1.51	1.51
368.37	2.03	2.03
313.34	1.60	1.60
364.38	2.06	2.06
402.45	1.94	1.94
336.34	1.09	1.09
282.30	1.63	1.63
332.38	1.34	1.34
310.36	0.92	0.92
316.75	2.28	2.28
343.36	1.52	1.52
364.38	2.31	2.31
326.79	2.69	2.69
299.31	1.50	1.50
365.41	3.22	3.22
299.38	1.07	1.07
351.35	1.22	1.22
374.38	2.30	2.30
315.38	0.99	0.99
313.34	1.51	1.51
348.35	0.98	0.98
313.19	3.01	3.01
335.41	2.00	2.00
314.39	1.59	1.59
382.85	3.04	3.04
314.39	1.67	1.67
374.45	2.64	2.64
311.35	1.67	1.67
350.36	1.82	1.82
391.48	2.38	2.38
338.37	1.98	1.98
300.36	1.32	1.32
335.37	1.25	1.25
353.36	1.16	1.16
351.41	1.72	1.72
311.32	1.57	1.57
293.33	1.43	1.43
327.36	1.90	1.90
325.80	3.29	3.29
350.36	1.82	1.82
327.36	1.82	1.82
406.49	3.25	3.25
312.40	2.34	2.34
337.38	1.71	1.71
327.36	1.95	1.95
388.48	2.68	2.68
350.38	1.23	1.23
358.30	2.74	2.74
342.36	1.64	1.64
343.34	2.02	2.02
364.41	2.46	2.46
391.48	2.41	2.41
390.45	2.17	2.17
412.44	1.97	1.97
302.35	1.71	1.71
391.48	2.41	2.41
336.37	2.52	2.52
360.85	1.80	1.80
300.36	1.36	1.36
335.37	1.02	1.02
327.36	1.82	1.82
282.31	0.76	0.76
334.42	3.34	3.34
356.39	2.16	2.16
300.36	0.81	0.81
347.42	1.93	1.93
285.35	1.14	1.14
339.37	1.85	1.85
340.39	0.46	0.46
349.40	1.59	1.59
325.37	1.38	1.38
356.81	2.70	2.70
327.34	1.37	1.37
324.31	2.72	2.72
347.42	1.93	1.93
362.44	2.10	2.10
374.45	2.33	2.33
299.16	2.67	2.67
348.41	2.20	2.20
310.36	2.24	2.24
312.33	1.64	1.64
308.74	2.50	2.50
324.39	1.56	1.56
336.40	1.54	1.54
310.36	1.08	1.08
299.31	1.72	1.72
312.33	1.64	1.64
347.42	1.93	1.93