Basic Information
ID: ALA4418432
Type: Binding
Description: Inhibition of CYP8B1 in human liver microsomes using D7-7alpha-hydroxy-4-cholesten-3-one as substrate preincubated for 20 mins followed by substrate addition in presence of NADPH by UPLC-ESI-MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4418432
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 531.44 | 4.21 | 4.21 |
| 416.13 | 6.45 | 6.45 |
| 344.85 | 5.38 | 5.38 |
| 381.69 | 5.80 | 5.80 |
| 705.65 | 5.58 | 5.58 |
| 133.19 | 1.50 | 1.50 |
| 700.79 | 4.57 | 4.57 |
| 387.72 | 5.86 | 5.86 |
| 420.68 | 5.41 | 5.41 |