Assay Report Card

Basic Information

ID: ALA4418444

Type: Binding

Description: Inhibition of untagged human USP30 catalytic domain (57 to 517 residues) expressed in Escherichia coli using TAMRA labeled ubiquitin peptide as substrate preincubated for 30 min followed by substrate addition and measured after 2 hrs by fluorescence polarization assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4418444

IC50

Total(78)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
391.50	0.69	0.69
335.43	0.20	0.20
391.50	0.84	0.84
373.44	1.65	1.65
377.43	-0.04	-0.04
398.49	2.28	2.28
407.50	0.45	0.45
336.42	0.44	0.44
359.41	1.26	1.26
404.54	0.61	0.61
358.43	1.11	1.11
368.46	2.11	2.11
407.45	-0.67	-0.67
379.45	-0.76	-0.76
342.42	2.16	2.16
424.53	0.10	0.10
398.49	2.28	2.28
372.45	1.15	1.15
411.92	1.10	1.10
377.47	0.45	0.45
391.50	0.83	0.83
354.44	2.38	2.38
368.46	2.28	2.28
372.45	1.39	1.39
369.45	1.67	1.67
342.42	2.16	2.16
359.41	1.26	1.26
369.45	1.67	1.67
378.46	-0.16	-0.16
414.41	1.89	1.89
374.35	1.38	1.38
363.40	-0.06	-0.06
368.46	2.28	2.28
306.39	0.43	0.43
377.47	0.45	0.45
306.39	1.00	1.00
368.46	2.31	2.31
398.49	2.28	2.28
382.49	2.52	2.52
354.44	2.38	2.38
377.43	-0.04	-0.04
368.46	2.41	2.41
369.45	1.67	1.67
398.49	2.28	2.28
292.36	0.61	0.61
398.49	2.28	2.28
292.36	0.44	0.44
292.36	0.61	0.61
386.48	1.40	1.40
334.45	1.26	1.26
354.44	2.31	2.31
294.38	0.85	0.85
377.43	-0.04	-0.04
368.46	2.28	2.28
363.40	-0.06	-0.06
372.45	1.01	1.01
362.46	0.08	0.08
368.46	2.28	2.28
369.45	1.67	1.67
382.49	2.67	2.67
278.34	0.74	0.74
391.50	-0.24	-0.24
292.36	0.74	0.74
392.49	0.23	0.23
368.46	2.11	2.11
378.46	-0.16	-0.16
369.45	1.67	1.67
382.49	2.67	2.67
400.39	1.50	1.50
398.49	2.28	2.28
395.49	2.25	2.25
364.43	-0.05	-0.05
369.45	1.67	1.67
355.42	1.71	1.71
369.45	1.67	1.67
368.46	2.41	2.41
358.43	1.00	1.00
363.44	0.55	0.55