Assay Report Card

Basic Information

ID: ALA4418453

Type: Binding

Description: Inhibition of recombinant His6-SUMO tagged human CGAS expressed in Escherichia coli BL21/pLys cells incubated for 20 mins by Kinase Glo chemiluminescence assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4418453

IC50

Total(298)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
189.17	0.26	0.26
206.23	1.41	1.41
206.23	1.41	1.41
437.27	3.90	3.90
375.20	3.61	3.61
356.24	3.94	3.94
489.71	3.56	3.56
443.12	4.65	4.65
436.29	3.75	3.75
418.19	4.78	4.78
454.28	3.89	3.89
334.19	3.88	3.88
454.33	4.15	4.15
437.28	2.77	2.77
489.30	2.83	2.83
438.26	2.90	2.90
378.25	4.28	4.28
436.29	3.38	3.38
542.37	3.84	3.84
492.40	4.86	4.86
441.31	4.85	4.85
454.28	3.64	3.64
364.22	3.89	3.89
436.29	3.38	3.38
567.42	4.60	4.60
207.21	0.80	0.80
528.39	4.20	4.20
452.29	2.48	2.48
481.30	4.54	4.54
324.79	1.13	1.13
488.32	3.38	3.38
339.17	2.39	2.39
451.30	3.33	3.33
484.35	2.93	2.93
513.37	4.93	4.93
451.30	3.23	3.23
337.20	3.60	3.60
457.31	3.83	3.83
462.33	4.07	4.07
527.40	4.80	4.80
502.80	4.57	4.57
568.47	4.85	4.85
566.41	5.39	5.39
441.31	4.85	4.85
437.27	3.09	3.09
310.76	0.74	0.74
546.38	4.34	4.34
533.43	5.38	5.38
386.27	3.86	3.86
475.30	3.97	3.97
517.36	2.65	2.65
479.36	4.01	4.01
299.74	2.72	2.72
465.33	3.26	3.26
330.16	2.53	2.53
378.19	3.93	3.93
505.39	3.66	3.66
531.43	4.75	4.75
382.16	3.84	3.84
464.41	5.33	5.33
456.71	3.84	3.84
514.36	4.33	4.33
467.30	2.78	2.78
396.23	2.30	2.30
382.21	4.03	4.03
299.35	3.43	3.43
514.36	4.33	4.33
436.29	3.50	3.50
342.21	3.38	3.38
532.42	4.15	4.15
528.39	4.20	4.20
369.24	1.24	1.24
477.34	3.76	3.76
435.30	4.10	4.10
440.25	3.33	3.33
560.36	3.98	3.98
471.34	4.14	4.14
513.35	3.39	3.39
465.33	3.39	3.39
289.31	2.05	2.05
410.25	3.12	3.12
457.31	3.83	3.83
467.28	3.38	3.38
439.26	3.93	3.93
471.33	4.95	4.95
446.29	1.72	1.72
469.29	3.47	3.47
515.39	4.21	4.21
444.31	3.56	3.56
483.34	5.68	5.68
488.32	3.38	3.38
483.37	3.92	3.92
205.24	1.22	1.22
365.21	3.28	3.28
274.22	2.42	2.42
505.39	4.18	4.18
426.33	4.78	4.78
451.30	3.33	3.33
360.25	3.63	3.63
498.38	3.92	3.92
487.73	4.70	4.70
442.29	4.25	4.25
548.42	5.26	5.26
483.34	5.68	5.68
360.25	2.99	2.99
421.27	3.79	3.79
490.77	5.46	5.46
518.80	3.58	3.58
541.38	4.44	4.44
480.41	4.34	4.34
506.38	4.39	4.39
471.34	4.29	4.29
495.33	3.79	3.79
455.27	2.91	2.91
503.35	4.84	4.84
454.33	3.48	3.48
474.70	3.98	3.98
487.34	3.98	3.98
355.17	2.55	2.55
534.80	3.25	3.25
451.30	3.08	3.08
355.21	0.85	0.85
378.63	3.48	3.48
469.29	3.37	3.37
333.29	3.09	3.09
505.40	2.96	2.96
396.18	3.93	3.93
512.41	3.54	3.54
528.38	4.12	4.12
364.22	3.89	3.89
499.35	4.25	4.25
362.18	2.97	2.97
362.25	4.44	4.44
471.33	5.46	5.46
502.75	4.93	4.93
420.28	4.40	4.40
344.19	2.83	2.83
279.32	2.38	2.38
457.31	5.16	5.16
483.32	3.93	3.93
421.29	2.50	2.50
451.30	2.81	2.81
489.33	4.43	4.43
457.31	5.16	5.16
488.32	3.38	3.38
356.20	3.02	3.02
505.27	3.50	3.50
391.19	2.67	2.67
358.21	3.22	3.22
441.35	3.54	3.54
541.38	4.44	4.44
406.26	4.61	4.61
376.28	5.00	5.00
355.19	3.74	3.74
402.19	4.90	4.90
368.21	2.83	2.83
452.24	3.92	3.92
437.28	2.77	2.77
496.29	4.84	4.84
546.38	4.34	4.34
507.37	3.03	3.03
283.28	2.21	2.21
423.24	3.30	3.30
450.31	4.06	4.06
532.42	4.15	4.15
484.35	3.32	3.32
438.26	2.90	2.90
507.32	4.67	4.67
357.23	2.70	2.70
536.30	4.64	4.64
514.36	4.33	4.33
514.45	4.63	4.63
497.41	4.09	4.09
398.67	4.54	4.54
491.37	3.79	3.79
314.16	2.82	2.82
453.32	4.42	4.42
385.28	3.48	3.48
190.16	-0.34	-0.34
416.22	4.98	4.98
246.29	2.11	2.11
541.38	4.44	4.44
498.36	4.86	4.86
509.38	3.81	3.81
421.27	3.79	3.79
422.26	3.59	3.59
437.28	2.77	2.77
465.33	3.64	3.64
367.22	2.09	2.09
497.37	4.71	4.71
495.33	3.44	3.44
269.25	1.90	1.90
353.20	1.78	1.78
499.32	2.83	2.83
448.28	3.77	3.77
475.26	3.39	3.39
527.40	4.61	4.61
290.30	1.94	1.94
535.41	3.90	3.90
423.08	3.55	3.55
484.31	2.54	2.54
495.36	3.16	3.16
479.35	4.14	4.14
437.27	3.09	3.09
469.29	3.22	3.22
468.35	3.91	3.91
195.20	0.73	0.73
623.53	4.91	4.91
459.32	4.88	4.88
478.30	2.42	2.42
474.31	4.70	4.70
566.41	5.39	5.39
455.33	5.41	5.41
470.73	4.40	4.40
520.41	2.94	2.94
525.31	4.85	4.85
220.25	1.80	1.80
421.27	4.31	4.31
398.16	3.72	3.72
499.32	2.83	2.83
462.32	4.69	4.69
483.32	3.86	3.86
461.29	5.06	5.06
527.40	4.80	4.80
519.42	4.00	4.00
410.25	3.12	3.12
470.35	4.87	4.87
452.29	3.20	3.20
541.38	4.44	4.44
528.39	4.20	4.20
363.23	4.49	4.49
471.33	4.95	4.95
435.30	3.84	3.84
370.22	3.39	3.39
359.21	3.44	3.44
411.22	3.73	3.73
548.42	5.26	5.26
499.35	4.25	4.25
533.43	5.38	5.38
501.36	3.65	3.65
471.33	4.95	4.95
456.32	4.56	4.56
513.37	4.55	4.55
291.33	2.38	2.38
471.34	4.39	4.39
548.42	5.26	5.26
515.39	4.31	4.31
436.29	3.38	3.38
360.25	3.54	3.54
461.30	3.67	3.67
483.32	3.34	3.34
505.27	3.79	3.79
207.21	0.80	0.80
451.30	4.20	4.20
220.25	1.71	1.71
465.33	3.79	3.79
471.33	4.95	4.95
435.30	2.98	2.98
546.38	4.34	4.34
471.33	4.95	4.95
532.42	4.15	4.15
421.27	3.79	3.79
468.30	3.37	3.37
504.39	3.99	3.99
530.38	2.60	2.60
470.30	3.47	3.47
471.33	4.95	4.95
499.32	2.73	2.73
365.21	3.28	3.28
541.38	4.44	4.44
462.30	3.70	3.70
477.34	3.65	3.65
446.28	3.79	3.79
514.38	2.94	2.94
371.26	3.09	3.09
527.40	4.80	4.80
407.25	4.01	4.01
439.29	2.77	2.77
506.38	2.60	2.60
497.39	4.23	4.23
437.28	2.77	2.77
476.74	4.90	4.90
469.29	3.47	3.47
428.29	3.77	3.77
422.26	3.59	3.59
469.29	2.95	2.95
455.27	2.91	2.91
493.38	4.26	4.26
428.31	4.85	4.85
382.21	4.03	4.03
522.38	4.12	4.12
358.21	3.22	3.22
489.33	4.53	4.53
462.35	5.01	5.01
499.35	4.25	4.25
483.28	2.59	2.59
510.77	5.17	5.17
422.26	3.19	3.19