Basic Information
ID: ALA4418456
Type: Binding
Description: Inhibition of CYP8B1 in human liver microsomes using 7alpha-hydroxy-4-cholesten-3-one as substrate preincubated followed by substrate addition in presence of NADPH and measured after 45 mins by ESI-MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4418456
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 478.91 | 4.00 | 4.00 |
| 528.46 | 4.25 | 4.25 |
| 526.49 | 4.68 | 4.68 |
| 512.46 | 4.37 | 4.37 |
| 557.58 | 3.24 | 3.24 |
| 462.45 | 3.49 | 3.49 |
| 518.02 | 4.52 | 4.52 |
| 562.90 | 4.26 | 4.26 |
| 513.35 | 4.66 | 4.66 |
| 562.90 | 4.90 | 4.90 |
| 478.91 | 4.00 | 4.00 |
| 547.58 | 3.24 | 3.24 |
| 522.55 | 2.75 | 2.75 |
| 479.89 | 3.40 | 3.40 |
| 549.00 | 4.79 | 4.79 |
| 545.95 | 4.66 | 4.66 |
| 522.52 | 4.77 | 4.77 |
| 520.94 | 4.21 | 4.21 |
| 522.96 | 4.06 | 4.06 |
| 508.93 | 4.01 | 4.01 |
| 546.90 | 5.02 | 5.02 |
| 515.54 | 3.10 | 3.10 |
| 475.48 | 2.75 | 2.75 |
| 518.97 | 4.88 | 4.88 |
| 474.49 | 3.36 | 3.36 |
| 550.59 | 4.93 | 4.93 |
| 552.00 | 3.14 | 3.14 |
| 542.94 | 5.12 | 5.12 |
| 496.90 | 4.14 | 4.14 |
| 561.01 | 3.81 | 3.81 |
| 534.53 | 5.16 | 5.16 |
| 557.00 | 3.41 | 3.41 |
| 494.47 | 4.29 | 4.29 |
| 545.95 | 5.60 | 5.60 |
| 460.46 | 3.06 | 3.06 |
| 608.49 | 3.94 | 3.94 |
| 531.51 | 3.12 | 3.12 |
| 538.02 | 3.62 | 3.62 |
| 514.55 | 4.14 | 4.14 |
| 606.96 | 4.31 | 4.31 |
| 512.46 | 4.37 | 4.37 |
| 526.92 | 4.15 | 4.15 |
| 508.50 | 4.46 | 4.46 |
| 512.46 | 4.43 | 4.43 |
| 541.58 | 3.49 | 3.49 |
| 509.92 | 3.41 | 3.41 |
| 496.90 | 4.14 | 4.14 |
| 511.51 | 2.93 | 2.93 |
| 492.93 | 4.31 | 4.31 |
| 521.55 | 4.41 | 4.41 |
| 529.57 | 3.49 | 3.49 |
| 496.90 | 4.14 | 4.14 |
| 534.51 | 3.67 | 3.67 |
| 469.47 | 3.22 | 3.22 |
| 514.55 | 4.24 | 4.24 |
| 462.45 | 3.49 | 3.49 |
| 610.92 | 4.14 | 4.14 |
| 549.99 | 3.75 | 3.75 |
| 546.90 | 5.08 | 5.08 |
| 547.89 | 4.42 | 4.42 |
| 520.99 | 4.23 | 4.23 |
| 549.60 | 3.49 | 3.49 |
| 490.51 | 4.11 | 4.11 |
| 511.51 | 4.00 | 4.00 |
| 519.48 | 3.27 | 3.27 |
| 557.80 | 4.77 | 4.77 |
| 459.48 | 3.05 | 3.05 |
| 565.95 | 3.77 | 3.77 |
| 513.45 | 3.76 | 3.76 |
| 478.91 | 4.00 | 4.00 |
| 520.56 | 5.02 | 5.02 |
| 510.47 | 3.95 | 3.95 |
| 526.49 | 4.60 | 4.60 |
| 530.45 | 4.51 | 4.51 |
| 475.48 | 2.75 | 2.75 |
| 528.91 | 4.94 | 4.94 |
| 478.91 | 4.00 | 4.00 |
| 476.48 | 3.80 | 3.80 |
| 494.47 | 3.94 | 3.94 |
| 525.54 | 4.31 | 4.31 |
| 553.59 | 3.63 | 3.63 |