Basic Information
ID: ALA4418462
Type: Binding
Description: Inhibition of recombinant His-tagged human ATG7 incubated for 105 mins in presence of GST-tagged ATG3 and Flag-tagged Gabarap and measured after 2 hrs by FRET assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4418462
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 431.46 | -1.75 | -1.75 |
| 456.48 | 0.57 | 0.57 |
| 434.48 | -0.13 | -0.13 |
| 472.94 | 1.08 | 1.08 |
| 472.48 | -0.69 | -0.69 |
| 482.54 | -0.15 | -0.15 |
| 524.48 | 1.40 | 1.40 |
| 436.49 | 0.12 | 0.12 |
| 394.41 | -1.05 | -1.05 |
| 504.55 | 0.55 | 0.55 |
| 456.48 | 0.57 | 0.57 |
| 426.43 | -0.37 | -0.37 |
| 492.92 | -0.21 | -0.21 |
| 450.52 | 0.36 | 0.36 |
| 396.33 | -1.12 | -1.12 |
| 384.37 | -2.38 | -2.38 |
| 446.51 | -0.72 | -0.72 |
| 479.56 | -0.34 | -0.34 |
| 488.94 | 0.05 | 0.05 |
| 496.53 | 0.20 | 0.20 |
| 466.48 | -1.04 | -1.04 |
| 450.52 | 0.51 | 0.51 |
| 474.50 | -0.75 | -0.75 |
| 422.46 | -0.27 | -0.27 |
| 456.22 | -1.12 | -1.12 |
| 452.52 | 0.74 | 0.74 |
| 497.49 | -0.58 | -0.58 |
| 525.47 | 0.79 | 0.79 |
| 494.60 | 1.73 | 1.73 |
| 396.33 | -1.81 | -1.81 |
| 394.41 | -1.05 | -1.05 |
| 472.55 | -0.16 | -0.16 |
| 398.32 | -0.70 | -0.70 |
| 371.34 | -2.88 | -2.88 |
| 486.51 | 0.58 | 0.58 |
| 434.50 | -1.00 | -1.00 |
| 406.45 | -1.64 | -1.64 |
| 450.47 | -0.89 | -0.89 |
| 457.47 | -0.23 | -0.23 |
| 458.48 | -1.87 | -1.87 |
| 474.50 | -0.75 | -0.75 |
| 482.54 | 0.10 | 0.10 |
| 471.50 | 0.08 | 0.08 |
| 360.35 | -1.71 | -1.71 |
| 488.55 | 1.58 | 1.58 |
| 522.49 | 1.33 | 1.33 |
| 452.52 | 0.57 | 0.57 |
| 469.51 | -1.06 | -1.06 |
| 452.45 | -1.17 | -1.17 |
| 476.43 | 0.27 | 0.27 |
| 404.41 | -2.52 | -2.52 |
| 452.52 | 0.74 | 0.74 |
| 436.49 | 0.12 | 0.12 |
| 388.38 | -0.90 | -0.90 |
| 438.46 | -1.30 | -1.30 |
| 360.35 | -1.71 | -1.71 |
| 473.92 | 0.48 | 0.48 |
| 456.48 | 0.57 | 0.57 |
| 436.49 | 0.12 | 0.12 |
| 438.46 | -1.04 | -1.04 |
| 370.35 | -2.77 | -2.77 |
| 482.50 | 0.16 | 0.16 |
| 426.43 | -0.37 | -0.37 |
| 404.41 | -1.96 | -1.96 |
| 468.52 | -0.29 | -0.29 |
| 452.52 | 0.74 | 0.74 |
| 456.48 | 0.57 | 0.57 |
| 448.38 | -0.16 | -0.16 |
| 471.50 | 0.08 | 0.08 |
| 380.33 | -0.79 | -0.79 |
| 422.45 | -2.67 | -2.67 |
| 444.46 | -1.88 | -1.88 |
| 470.51 | 0.68 | 0.68 |
| 508.61 | 1.78 | 1.78 |
| 405.42 | -3.12 | -3.12 |
| 462.51 | -1.75 | -1.75 |
| 462.51 | -1.48 | -1.48 |
| 389.35 | -3.65 | -3.65 |
| 491.91 | 0.42 | 0.42 |
| 525.47 | 0.79 | 0.79 |
| 404.47 | -0.22 | -0.22 |
| 408.42 | -3.01 | -3.01 |
| 376.42 | -1.00 | -1.00 |
| 468.52 | 0.44 | 0.44 |
| 524.48 | 1.40 | 1.40 |
| 468.52 | -0.29 | -0.29 |
| 390.38 | -2.70 | -2.70 |
| 399.39 | -3.44 | -3.44 |
| 502.47 | -0.32 | -0.32 |
| 404.47 | -0.22 | -0.22 |
| 438.42 | -0.96 | -0.96 |
| 473.92 | 0.48 | 0.48 |
| 458.48 | -0.70 | -0.70 |
| 386.39 | -1.87 | -1.87 |
| 470.51 | 0.52 | 0.52 |
| 488.94 | 0.05 | 0.05 |
| 518.58 | 0.69 | 0.69 |
| 486.51 | -0.32 | -0.32 |
| 490.93 | 1.03 | 1.03 |
| 385.36 | -2.69 | -2.69 |
| 412.39 | -2.36 | -2.36 |
| 450.50 | -1.89 | -1.89 |
| 507.55 | -0.05 | -0.05 |
| 488.55 | 1.58 | 1.58 |
| 433.45 | -0.77 | -0.77 |
| 488.94 | 0.05 | 0.05 |
| 468.52 | -0.46 | -0.46 |
| 459.54 | 0.19 | 0.19 |
| 445.51 | -0.12 | -0.12 |
| 474.47 | 0.52 | 0.52 |
| 460.47 | -0.89 | -0.89 |
| 480.53 | 0.36 | 0.36 |
| 471.50 | 0.08 | 0.08 |
| 498.54 | -0.45 | -0.45 |
| 344.35 | -1.41 | -1.41 |
| 474.47 | 0.52 | 0.52 |
| 482.48 | -0.36 | -0.36 |
| 390.45 | -0.61 | -0.61 |
| 481.49 | 0.25 | 0.25 |
| 448.50 | 0.26 | 0.26 |
| 472.22 | -2.15 | -2.15 |
| 482.54 | -0.42 | -0.42 |
| 422.42 | -1.09 | -1.09 |
| 496.55 | 1.06 | 1.06 |
| 415.46 | -0.72 | -0.72 |
| 434.48 | -0.27 | -0.27 |
| 412.40 | -0.41 | -0.41 |
| 484.48 | 0.36 | 0.36 |
| 476.54 | -1.36 | -1.36 |
| 436.47 | -2.28 | -2.28 |
| 414.32 | -1.73 | -1.73 |
| 402.46 | -0.47 | -0.47 |
| 482.54 | -0.15 | -0.15 |
| 498.54 | 0.45 | 0.45 |
| 472.94 | 1.08 | 1.08 |
| 455.48 | -1.21 | -1.21 |
| 398.32 | -0.70 | -0.70 |
| 482.54 | -0.15 | -0.15 |
| 424.82 | -2.13 | -2.13 |
| 376.35 | -3.26 | -3.26 |
| 478.56 | 0.92 | 0.92 |
| 436.49 | 0.12 | 0.12 |
| 471.50 | -0.09 | -0.09 |
| 428.40 | -1.44 | -1.44 |
| 375.37 | -3.29 | -3.29 |
| 470.46 | -0.03 | -0.03 |
| 523.38 | 0.71 | 0.71 |
| 460.47 | -0.89 | -0.89 |
| 418.50 | 0.17 | 0.17 |
| 434.50 | -0.86 | -0.86 |
| 496.57 | 1.22 | 1.22 |
| 490.56 | -0.96 | -0.96 |
| 474.50 | 0.59 | 0.59 |
| 429.44 | -1.63 | -1.63 |
| 412.33 | -2.15 | -2.15 |
| 406.45 | -1.89 | -1.89 |
| 448.50 | 0.12 | 0.12 |
| 460.47 | -0.89 | -0.89 |
| 468.52 | -0.29 | -0.29 |
| 536.51 | 0.56 | 0.56 |
| 470.51 | 0.88 | 0.88 |
| 460.47 | 0.28 | 0.28 |
| 376.42 | -1.00 | -1.00 |
| 430.39 | -0.46 | -0.46 |
| 469.51 | -1.06 | -1.06 |
| 449.52 | -2.10 | -2.10 |
| 388.41 | -1.63 | -1.63 |
| 439.48 | -0.18 | -0.18 |
| 414.32 | -1.17 | -1.17 |
| 416.44 | -2.03 | -2.03 |
| 552.51 | 0.44 | 0.44 |
| 419.45 | -2.15 | -2.15 |
| 489.54 | 0.98 | 0.98 |
| 416.49 | -0.08 | -0.08 |
| 374.38 | -2.19 | -2.19 |
| 420.47 | -1.25 | -1.25 |
| 388.36 | -2.55 | -2.55 |
| 452.52 | 0.74 | 0.74 |
| 490.93 | 1.03 | 1.03 |
| 462.53 | 0.65 | 0.65 |
| 413.37 | -2.10 | -2.10 |
| 448.50 | -0.03 | -0.03 |
| 433.47 | -2.69 | -2.69 |
| 416.49 | -0.22 | -0.22 |
| 404.36 | -2.97 | -2.97 |
| 390.45 | -0.61 | -0.61 |
| 447.50 | -1.54 | -1.54 |
| 466.55 | 1.05 | 1.05 |
| 376.35 | -2.74 | -2.74 |
| 402.39 | -2.19 | -2.19 |
| 478.56 | 0.92 | 0.92 |
| 487.50 | -0.22 | -0.22 |
| 477.53 | 0.91 | 0.91 |
| 404.41 | -2.04 | -2.04 |
| 346.33 | -2.75 | -2.75 |
| 456.48 | 0.57 | 0.57 |
| 378.34 | -1.77 | -1.77 |
| 472.48 | -0.69 | -0.69 |
| 457.47 | -0.23 | -0.23 |
| 450.48 | -0.97 | -0.97 |
| 436.47 | -2.01 | -2.01 |
| 372.36 | -2.11 | -2.11 |
| 470.51 | 0.88 | 0.88 |
| 390.38 | -2.61 | -2.61 |
| 480.53 | 0.36 | 0.36 |
| 474.47 | 0.52 | 0.52 |
| 392.42 | -2.03 | -2.03 |
| 454.49 | -0.60 | -0.60 |
| 522.49 | 1.33 | 1.33 |
| 460.42 | -1.10 | -1.10 |
| 392.42 | -2.03 | -2.03 |
| 420.47 | -1.25 | -1.25 |
| 432.48 | -1.25 | -1.25 |
| 471.50 | -0.09 | -0.09 |
| 358.38 | -1.16 | -1.16 |
| 390.38 | -2.35 | -2.35 |
| 432.48 | -1.11 | -1.11 |
| 360.35 | -2.44 | -2.44 |
| 424.44 | -1.69 | -1.69 |
| 471.50 | -0.09 | -0.09 |
| 406.45 | -1.64 | -1.64 |
| 330.33 | -1.72 | -1.72 |
| 448.50 | 0.12 | 0.12 |
| 486.51 | 0.58 | 0.58 |
| 486.51 | -0.32 | -0.32 |
| 457.47 | -0.23 | -0.23 |
| 414.40 | -2.75 | -2.75 |
| 418.46 | -1.50 | -1.50 |