Inhibition of wild type full length human PAICS using CAIR as substrate preincubated for 30 mins followed by substrate addition and measured after 1 h...

Basic Information

ID: ALA4418466

Type: Binding

Description: Inhibition of wild type full length human PAICS using CAIR as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by ADP2 tracer-based fluorescence assay

Format: BAO_0000357

Organism: Homo sapiens

Target: Multifunctional protein ADE2(ALA5922)

Document: ALA4418316

Inhibition of wild type full length human PAICS using CAIR as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by ADP2 tracer-based fluorescence assay: 38

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4418466

IC50

Total(63)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
446.96	3.47	3.47
386.84	2.95	2.95
399.84	2.97	2.97
411.89	3.23	3.23
433.56	3.69	3.69
400.87	3.29	3.29
429.91	3.99	3.99
372.82	2.51	2.51
421.91	3.62	3.62
426.91	2.97	2.97
418.91	2.69	2.69
400.87	3.77	3.77
388.86	3.03	3.03
414.90	3.73	3.73
429.91	2.32	2.32
418.91	3.04	3.04
386.84	2.95	2.95
449.96	4.40	4.40
402.84	2.56	2.56
386.84	2.95	2.95
429.91	2.27	2.27
374.83	2.64	2.64
430.56	2.76	2.76
446.96	3.47	3.47
427.53	3.62	3.62
418.91	2.69	2.69
440.94	3.58	3.58
405.91	3.78	3.78
457.92	2.24	2.24
427.89	3.60	3.60
415.88	3.56	3.56
401.85	3.16	3.16
401.85	3.21	3.21
471.95	2.44	2.44
419.89	3.42	3.42
485.98	3.14	3.14
414.85	2.75	2.75
412.88	2.63	2.63
421.91	3.62	3.62
413.87	3.36	3.36
360.81	2.25	2.25
460.99	3.81	3.81
374.83	2.64	2.64
415.88	3.56	3.56
471.95	2.58	2.58
397.87	3.24	3.24
500.00	3.53	3.53
443.94	2.66	2.66
438.92	2.88	2.88
471.95	2.75	2.75
411.85	2.82	2.82
412.88	2.98	2.98
430.90	2.66	2.66
443.90	1.85	1.85
388.86	2.98	2.98
440.94	3.41	3.41
372.82	2.56	2.56
400.87	3.26	3.26
446.96	3.47	3.47
415.89	1.93	1.93
460.99	3.72	3.72
431.88	1.70	1.70
400.87	3.17	3.17