Basic Information
ID: ALA4418466
Type: Binding
Description: Inhibition of wild type full length human PAICS using CAIR as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by ADP2 tracer-based fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4418466
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 446.96 | 3.47 | 3.47 |
| 386.84 | 2.95 | 2.95 |
| 399.84 | 2.97 | 2.97 |
| 411.89 | 3.23 | 3.23 |
| 433.56 | 3.69 | 3.69 |
| 400.87 | 3.29 | 3.29 |
| 429.91 | 3.99 | 3.99 |
| 372.82 | 2.51 | 2.51 |
| 421.91 | 3.62 | 3.62 |
| 426.91 | 2.97 | 2.97 |
| 418.91 | 2.69 | 2.69 |
| 400.87 | 3.77 | 3.77 |
| 388.86 | 3.03 | 3.03 |
| 414.90 | 3.73 | 3.73 |
| 429.91 | 2.32 | 2.32 |
| 418.91 | 3.04 | 3.04 |
| 386.84 | 2.95 | 2.95 |
| 449.96 | 4.40 | 4.40 |
| 402.84 | 2.56 | 2.56 |
| 386.84 | 2.95 | 2.95 |
| 429.91 | 2.27 | 2.27 |
| 374.83 | 2.64 | 2.64 |
| 430.56 | 2.76 | 2.76 |
| 446.96 | 3.47 | 3.47 |
| 427.53 | 3.62 | 3.62 |
| 418.91 | 2.69 | 2.69 |
| 440.94 | 3.58 | 3.58 |
| 405.91 | 3.78 | 3.78 |
| 457.92 | 2.24 | 2.24 |
| 427.89 | 3.60 | 3.60 |
| 415.88 | 3.56 | 3.56 |
| 401.85 | 3.16 | 3.16 |
| 401.85 | 3.21 | 3.21 |
| 471.95 | 2.44 | 2.44 |
| 419.89 | 3.42 | 3.42 |
| 485.98 | 3.14 | 3.14 |
| 414.85 | 2.75 | 2.75 |
| 412.88 | 2.63 | 2.63 |
| 421.91 | 3.62 | 3.62 |
| 413.87 | 3.36 | 3.36 |
| 360.81 | 2.25 | 2.25 |
| 460.99 | 3.81 | 3.81 |
| 374.83 | 2.64 | 2.64 |
| 415.88 | 3.56 | 3.56 |
| 471.95 | 2.58 | 2.58 |
| 397.87 | 3.24 | 3.24 |
| 500.00 | 3.53 | 3.53 |
| 443.94 | 2.66 | 2.66 |
| 438.92 | 2.88 | 2.88 |
| 471.95 | 2.75 | 2.75 |
| 411.85 | 2.82 | 2.82 |
| 412.88 | 2.98 | 2.98 |
| 430.90 | 2.66 | 2.66 |
| 443.90 | 1.85 | 1.85 |
| 388.86 | 2.98 | 2.98 |
| 440.94 | 3.41 | 3.41 |
| 372.82 | 2.56 | 2.56 |
| 400.87 | 3.26 | 3.26 |
| 446.96 | 3.47 | 3.47 |
| 415.89 | 1.93 | 1.93 |
| 460.99 | 3.72 | 3.72 |
| 431.88 | 1.70 | 1.70 |
| 400.87 | 3.17 | 3.17 |