Basic Information
ID: ALA4418511
Type: Functional
Description: Antitumor activity against EML4-ALK fusion protein harboring human NCI-H2228 cells xenografted in NOD/SCID mouse assessed as inhibition of tumor growth at 1 mg/kg, po dosed once daily for 14 days starting 3 weeks of tumor cell inoculation and measured every other day relative to untreated control
Format: BAO_0000218
Organism: Homo sapiens
Cell type: NCI-H2228
Target: NCI-H2228(ALA1075536)
Document: ALA4418479
Antitumor activity against EML4-ALK fusion protein harboring human NCI-H2228 cells xenografted in NOD/SCID mouse assessed as inhibition of tumor growth at 1 mg/kg, po dosed once daily for 14 days starting 3 weeks of tumor cell inoculation and measured every other day relative to untreated control: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4418511
TGI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 536.73 | 3.25 | 3.25 |
| 487.61 | 3.50 | 3.50 |
| 342.45 | 2.16 | 2.16 |