Basic Information
ID: ALA4418719
Type: Binding
Description: Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production pre-incubated at room temperature for 5 mins before all-trans-retinol addition and further incubated for 15 mins to 2 hrs in presence of CRALBP by normal phase HPLC analysis
Format: BAO_0000019
Organism: Bos taurus
Target: Retinoid isomerohydrolase(ALA4523306)
Document: ALA4418488
Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production pre-incubated at room temperature for 5 mins before all-trans-retinol addition and further incubated for 15 mins to 2 hrs in presence of CRALBP by normal phase HPLC analysis: 38
Activity Charts
Bioactivity
Activity Types for Assay ALA4418719
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 245.41 | 4.53 | 4.53 |
| 327.56 | 6.50 | 6.50 |
| 266.39 | 4.04 | 4.04 |
| 301.47 | 4.45 | 4.45 |
| 271.40 | 4.18 | 4.18 |
| 265.40 | 4.64 | 4.64 |
| 376.46 | 5.16 | 5.16 |
| 335.54 | 6.01 | 6.01 |
| 305.46 | 5.59 | 5.59 |
| 327.56 | 6.50 | 6.50 |
| 285.48 | 5.48 | 5.48 |
| 311.51 | 6.03 | 6.03 |
| 369.64 | 7.53 | 7.53 |
| 369.43 | 6.26 | 6.26 |
| 271.45 | 5.09 | 5.09 |
| 281.44 | 5.13 | 5.13 |
| 259.44 | 4.92 | 4.92 |
| 335.49 | 5.60 | 5.60 |
| 261.41 | 3.50 | 3.50 |
| 301.47 | 4.45 | 4.45 |
| 332.45 | 4.65 | 4.65 |
| 261.41 | 3.50 | 3.50 |
| 327.51 | 5.00 | 5.00 |
| 269.43 | 4.98 | 4.98 |
| 295.47 | 5.07 | 5.07 |
| 245.41 | 4.53 | 4.53 |
| 335.88 | 5.90 | 5.90 |
| 243.39 | 4.45 | 4.45 |
| 299.50 | 5.87 | 5.87 |
| 347.46 | 4.96 | 4.96 |
| 243.39 | 4.31 | 4.31 |
| 257.42 | 4.70 | 4.70 |
| 287.49 | 5.56 | 5.56 |
| 327.51 | 5.00 | 5.00 |
| 285.48 | 5.48 | 5.48 |
| 305.47 | 5.73 | 5.73 |