Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visu...

ID: ALA4418735

Type: Functional

Description: Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visual chromophore recovery by measuring 11-cis- retinal level per eye at 0.1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 7 days by HPLC analysis (Rvb = 301+/- 8 pmol/eye)

Format: BAO_0000218

Organism: Mus musculus

Target:  Mus musculus(ALA375)

Document:  ALA4418488

Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visual chromophore recovery by measuring 11-cis- retinal level per eye at 0.1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 7 days by HPLC analysis (Rvb = 301+/- 8 pmol/eye): 38