ID: ALA4418739
Type: Binding
Description: Inhibition of FTO (unknown origin) assessed as reduction in demethylation by measuring N6-mA and A level incubated for 2 hrs by HPLC-MS/MS analysis
Organism: Homo sapiens
Bioactivity
Activity Types for Assay ALA4418739
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
305.29 | 1.78 | 1.78 |
359.73 | 3.21 | 3.21 |
317.30 | 1.93 | 1.93 |
319.27 | 0.77 | 0.77 |
319.27 | 1.12 | 1.12 |
348.30 | 1.89 | 1.89 |
352.27 | 1.34 | 1.34 |
299.24 | 1.70 | 1.70 |
349.30 | 3.21 | 3.21 |
334.33 | 1.33 | 1.33 |
354.35 | 2.97 | 2.97 |
350.29 | 2.60 | 2.60 |
343.25 | 1.87 | 1.87 |
284.23 | 1.86 | 1.86 |
350.29 | 2.60 | 2.60 |
283.24 | 2.47 | 2.47 |
305.25 | 1.08 | 1.08 |
333.29 | 1.40 | 1.40 |
382.36 | 3.16 | 3.16 |
333.28 | 2.22 | 2.22 |
334.29 | 0.41 | 0.41 |
326.27 | 1.95 | 1.95 |
300.23 | 1.10 | 1.10 |
303.27 | 1.54 | 1.54 |
284.23 | 1.86 | 1.86 |
339.31 | 2.23 | 2.23 |
360.37 | 1.82 | 1.82 |
315.24 | 2.09 | 2.09 |
370.33 | 0.61 | 0.61 |
304.26 | 0.43 | 0.43 |
328.24 | 0.81 | 0.81 |
305.27 | 2.41 | 2.41 |
299.25 | 1.15 | 1.15 |
307.22 | 0.11 | 0.11 |
356.30 | 0.31 | 0.31 |
371.31 | 1.21 | 1.21 |
305.25 | 1.03 | 1.03 |
300.23 | 1.10 | 1.10 |
305.25 | 0.43 | 0.43 |
317.22 | 0.62 | 0.62 |
321.29 | 1.67 | 1.67 |
361.35 | 2.42 | 2.42 |
349.28 | 1.29 | 1.29 |
357.28 | 0.91 | 0.91 |
335.27 | 1.01 | 1.01 |
348.30 | 0.69 | 0.69 |
344.24 | 1.44 | 1.44 |
289.25 | 1.15 | 1.15 |
333.29 | 1.40 | 1.40 |
300.23 | 1.75 | 1.75 |
302.25 | 0.78 | 0.78 |
313.27 | 2.65 | 2.65 |
275.22 | 0.76 | 0.76 |
298.26 | 1.75 | 1.75 |
314.26 | 2.05 | 2.05 |
284.23 | 1.86 | 1.86 |
332.30 | 2.01 | 2.01 |
299.25 | 1.15 | 1.15 |
283.24 | 2.47 | 2.47 |
347.28 | 0.99 | 0.99 |
341.28 | 1.02 | 1.02 |
346.32 | 1.80 | 1.80 |
344.24 | 1.15 | 1.15 |
316.23 | 0.67 | 0.67 |
297.27 | 2.77 | 2.77 |
277.24 | 1.05 | 1.05 |
333.28 | 2.14 | 2.14 |
339.33 | 3.68 | 3.68 |
388.41 | 2.97 | 2.97 |
290.26 | 1.92 | 1.92 |
327.26 | 1.34 | 1.34 |
342.27 | 0.89 | 0.89 |
356.30 | 0.31 | 0.31 |
304.29 | 1.81 | 1.81 |
284.23 | 1.86 | 1.86 |
360.35 | 2.19 | 2.19 |
300.23 | 1.75 | 1.75 |
284.23 | 1.86 | 1.86 |
289.27 | 2.53 | 2.53 |
304.26 | 0.48 | 0.48 |
300.23 | 1.45 | 1.45 |
317.22 | 0.06 | 0.06 |
297.27 | 2.77 | 2.77 |
302.21 | 0.24 | 0.24 |
317.21 | 1.49 | 1.49 |
283.24 | 2.47 | 2.47 |
355.33 | 3.57 | 3.57 |
332.30 | 1.54 | 1.54 |
342.27 | 0.63 | 0.63 |
293.24 | 0.93 | 0.93 |
317.28 | 2.25 | 2.25 |
313.27 | 2.17 | 2.17 |
343.25 | 1.23 | 1.23 |
337.24 | -0.53 | -0.53 |
312.29 | 2.05 | 2.05 |
292.25 | 0.34 | 0.34 |
328.24 | 1.56 | 1.56 |
312.24 | 1.59 | 1.59 |
265.18 | 0.42 | 0.42 |
299.24 | 1.70 | 1.70 |
291.22 | 0.69 | 0.69 |
314.25 | 2.70 | 2.70 |
305.25 | 0.73 | 0.73 |
320.31 | 1.07 | 1.07 |
299.24 | 2.35 | 2.35 |
325.28 | 2.55 | 2.55 |
343.26 | 0.84 | 0.84 |
321.25 | 0.50 | 0.50 |
347.31 | 1.29 | 1.29 |
301.22 | 0.84 | 0.84 |
293.24 | 0.02 | 0.02 |
331.33 | 2.36 | 2.36 |
313.27 | 1.45 | 1.45 |
350.29 | 2.67 | 2.67 |
285.22 | 1.26 | 1.26 |
331.33 | 2.32 | 2.32 |
377.31 | 2.57 | 2.57 |
332.32 | 1.21 | 1.21 |
333.30 | 1.81 | 1.81 |