Basic Information
ID: ALA4418739
Type: Binding
Description: Inhibition of FTO (unknown origin) assessed as reduction in demethylation by measuring N6-mA and A level incubated for 2 hrs by HPLC-MS/MS analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4418739
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 305.29 | 1.78 | 1.78 |
| 359.73 | 3.21 | 3.21 |
| 317.30 | 1.93 | 1.93 |
| 319.27 | 0.77 | 0.77 |
| 319.27 | 1.12 | 1.12 |
| 348.30 | 1.89 | 1.89 |
| 352.27 | 1.34 | 1.34 |
| 299.24 | 1.70 | 1.70 |
| 349.30 | 3.21 | 3.21 |
| 334.33 | 1.33 | 1.33 |
| 354.35 | 2.97 | 2.97 |
| 350.29 | 2.60 | 2.60 |
| 343.25 | 1.87 | 1.87 |
| 284.23 | 1.86 | 1.86 |
| 350.29 | 2.60 | 2.60 |
| 283.24 | 2.47 | 2.47 |
| 305.25 | 1.08 | 1.08 |
| 333.29 | 1.40 | 1.40 |
| 382.36 | 3.16 | 3.16 |
| 333.28 | 2.22 | 2.22 |
| 334.29 | 0.41 | 0.41 |
| 326.27 | 1.95 | 1.95 |
| 300.23 | 1.10 | 1.10 |
| 303.27 | 1.54 | 1.54 |
| 284.23 | 1.86 | 1.86 |
| 339.31 | 2.23 | 2.23 |
| 360.37 | 1.82 | 1.82 |
| 315.24 | 2.09 | 2.09 |
| 370.33 | 0.61 | 0.61 |
| 304.26 | 0.43 | 0.43 |
| 328.24 | 0.81 | 0.81 |
| 305.27 | 2.41 | 2.41 |
| 299.25 | 1.15 | 1.15 |
| 307.22 | 0.11 | 0.11 |
| 356.30 | 0.31 | 0.31 |
| 371.31 | 1.21 | 1.21 |
| 305.25 | 1.03 | 1.03 |
| 300.23 | 1.10 | 1.10 |
| 305.25 | 0.43 | 0.43 |
| 317.22 | 0.62 | 0.62 |
| 321.29 | 1.67 | 1.67 |
| 361.35 | 2.42 | 2.42 |
| 349.28 | 1.29 | 1.29 |
| 357.28 | 0.91 | 0.91 |
| 335.27 | 1.01 | 1.01 |
| 348.30 | 0.69 | 0.69 |
| 344.24 | 1.44 | 1.44 |
| 289.25 | 1.15 | 1.15 |
| 333.29 | 1.40 | 1.40 |
| 300.23 | 1.75 | 1.75 |
| 302.25 | 0.78 | 0.78 |
| 313.27 | 2.65 | 2.65 |
| 275.22 | 0.76 | 0.76 |
| 298.26 | 1.75 | 1.75 |
| 314.26 | 2.05 | 2.05 |
| 284.23 | 1.86 | 1.86 |
| 332.30 | 2.01 | 2.01 |
| 299.25 | 1.15 | 1.15 |
| 283.24 | 2.47 | 2.47 |
| 347.28 | 0.99 | 0.99 |
| 341.28 | 1.02 | 1.02 |
| 346.32 | 1.80 | 1.80 |
| 344.24 | 1.15 | 1.15 |
| 316.23 | 0.67 | 0.67 |
| 297.27 | 2.77 | 2.77 |
| 277.24 | 1.05 | 1.05 |
| 333.28 | 2.14 | 2.14 |
| 339.33 | 3.68 | 3.68 |
| 388.41 | 2.97 | 2.97 |
| 290.26 | 1.92 | 1.92 |
| 327.26 | 1.34 | 1.34 |
| 342.27 | 0.89 | 0.89 |
| 356.30 | 0.31 | 0.31 |
| 304.29 | 1.81 | 1.81 |
| 284.23 | 1.86 | 1.86 |
| 360.35 | 2.19 | 2.19 |
| 300.23 | 1.75 | 1.75 |
| 284.23 | 1.86 | 1.86 |
| 289.27 | 2.53 | 2.53 |
| 304.26 | 0.48 | 0.48 |
| 300.23 | 1.45 | 1.45 |
| 317.22 | 0.06 | 0.06 |
| 297.27 | 2.77 | 2.77 |
| 302.21 | 0.24 | 0.24 |
| 317.21 | 1.49 | 1.49 |
| 283.24 | 2.47 | 2.47 |
| 355.33 | 3.57 | 3.57 |
| 332.30 | 1.54 | 1.54 |
| 342.27 | 0.63 | 0.63 |
| 293.24 | 0.93 | 0.93 |
| 317.28 | 2.25 | 2.25 |
| 313.27 | 2.17 | 2.17 |
| 343.25 | 1.23 | 1.23 |
| 337.24 | -0.53 | -0.53 |
| 312.29 | 2.05 | 2.05 |
| 292.25 | 0.34 | 0.34 |
| 328.24 | 1.56 | 1.56 |
| 312.24 | 1.59 | 1.59 |
| 265.18 | 0.42 | 0.42 |
| 299.24 | 1.70 | 1.70 |
| 291.22 | 0.69 | 0.69 |
| 314.25 | 2.70 | 2.70 |
| 305.25 | 0.73 | 0.73 |
| 320.31 | 1.07 | 1.07 |
| 299.24 | 2.35 | 2.35 |
| 325.28 | 2.55 | 2.55 |
| 343.26 | 0.84 | 0.84 |
| 321.25 | 0.50 | 0.50 |
| 347.31 | 1.29 | 1.29 |
| 301.22 | 0.84 | 0.84 |
| 293.24 | 0.02 | 0.02 |
| 331.33 | 2.36 | 2.36 |
| 313.27 | 1.45 | 1.45 |
| 350.29 | 2.67 | 2.67 |
| 285.22 | 1.26 | 1.26 |
| 331.33 | 2.32 | 2.32 |
| 377.31 | 2.57 | 2.57 |
| 332.32 | 1.21 | 1.21 |
| 333.30 | 1.81 | 1.81 |