Basic Information
ID: ALA4418847
Type: Binding
Description: Inhibition of His-tagged human recombinant SHMT2 expressed in Escherichia coli BLR(DE3) assessed as reduction in NADPH level using L-serine, THF and NADP+ at 6.5 or 26.5 uM incubated for 5 mins by SHMT2-MTHFD coupled reaction based fluorescence assay relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4418847
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 190.25 | 1.68 | 1.68 |
| 259.35 | 2.78 | 2.78 |
| 187.20 | 1.02 | 1.02 |
| 212.30 | 2.25 | 2.25 |
| 339.39 | 3.86 | 3.86 |
| 481.51 | 4.63 | 4.63 |
| 395.47 | 4.23 | 4.23 |
| 197.23 | 0.87 | 0.87 |
| 292.14 | 1.76 | 1.76 |
| 277.33 | 3.29 | 3.29 |
| 215.26 | 1.65 | 1.65 |
| 337.42 | 3.67 | 3.67 |
| 401.53 | 2.90 | 2.90 |
| 297.42 | 4.63 | 4.63 |
| 248.28 | 1.56 | 1.56 |
| 304.32 | 2.98 | 2.98 |
| 441.40 | -0.04 | -0.04 |
| 606.72 | 6.87 | 6.87 |
| 158.12 | -2.18 | -2.18 |
| 394.47 | 6.04 | 6.04 |
| 382.53 | 5.31 | 5.31 |
| 230.26 | -2.34 | -2.34 |
| 261.32 | 1.75 | 1.75 |
| 270.26 | 3.45 | 3.45 |
| 246.35 | 2.73 | 2.73 |
| 354.45 | 2.65 | 2.65 |
| 166.22 | 2.37 | 2.37 |
| 338.74 | 2.72 | 2.72 |
| 354.45 | 2.65 | 2.65 |
| 318.50 | 4.60 | 4.60 |
| 341.41 | 3.17 | 3.17 |
| 288.38 | 2.86 | 2.86 |
| 536.62 | 2.33 | 2.33 |
| 394.29 | 3.65 | 3.65 |
| 334.50 | 3.57 | 3.57 |
| 375.97 | 3.67 | 3.67 |
| 316.81 | 4.86 | 4.86 |
| 416.56 | 2.68 | 2.68 |
| 295.29 | 1.35 | 1.35 |
| 211.24 | 1.28 | 1.28 |
| 319.16 | 2.67 | 2.67 |
| 460.91 | 4.29 | 4.29 |
| 570.64 | 4.08 | 4.08 |
| 464.74 | 6.19 | 6.19 |
| 279.86 | 4.74 | 4.74 |
| 307.37 | 3.69 | 3.69 |