Basic Information
ID: ALA4418848
Type: Binding
Description: Inhibition of His-tagged human recombinant SHMT2 expressed in Escherichia coli BLR(DE3) assessed as reduction in NADPH level using L-serine, THF and NADP+ incubated for 5 mins by SHMT2-MTHFD coupled reaction based fluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4418848
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 259.35 | 2.78 | 2.78 |
| 339.39 | 3.86 | 3.86 |
| 395.47 | 4.23 | 4.23 |
| 293.32 | 4.03 | 4.03 |
| 297.42 | 4.63 | 4.63 |
| 304.32 | 2.98 | 2.98 |
| 357.37 | 1.26 | 1.26 |
| 382.53 | 5.31 | 5.31 |
| 397.43 | 4.09 | 4.09 |
| 271.28 | 1.94 | 1.94 |
| 458.54 | 2.73 | 2.73 |
| 365.39 | 3.46 | 3.46 |
| 294.76 | 3.41 | 3.41 |
| 399.52 | 3.95 | 3.95 |
| 286.38 | 3.02 | 3.02 |
| 421.46 | 4.98 | 4.98 |
| 306.39 | 4.01 | 4.01 |
| 331.76 | 3.79 | 3.79 |
| 353.85 | 3.06 | 3.06 |
| 371.49 | 2.95 | 2.95 |
| 331.76 | 3.79 | 3.79 |
| 268.36 | 2.53 | 2.53 |
| 438.96 | 4.67 | 4.67 |
| 319.41 | 2.41 | 2.41 |
| 372.43 | 4.38 | 4.38 |
| 343.43 | 3.81 | 3.81 |
| 410.97 | 5.30 | 5.30 |
| 361.49 | 4.61 | 4.61 |
| 387.84 | 5.09 | 5.09 |
| 341.34 | 3.06 | 3.06 |
| 327.43 | 3.72 | 3.72 |
| 320.40 | 3.03 | 3.03 |
| 388.51 | 3.43 | 3.43 |
| 341.43 | 4.49 | 4.49 |
| 440.89 | 4.53 | 4.53 |
| 371.39 | 4.58 | 4.58 |
| 363.46 | 4.54 | 4.54 |
| 264.35 | 2.47 | 2.47 |
| 352.82 | 3.03 | 3.03 |
| 329.38 | 3.00 | 3.00 |
| 458.50 | 3.89 | 3.89 |
| 373.42 | 3.95 | 3.95 |
| 271.27 | 3.52 | 3.52 |
| 468.60 | 5.41 | 5.41 |
| 247.25 | 0.73 | 0.73 |
| 298.33 | 1.93 | 1.93 |
| 345.38 | 2.97 | 2.97 |
| 326.40 | 5.05 | 5.05 |
| 308.34 | 2.26 | 2.26 |
| 386.46 | 3.96 | 3.96 |
| 316.36 | 2.13 | 2.13 |
| 432.53 | 3.05 | 3.05 |
| 434.50 | 1.97 | 1.97 |
| 440.54 | 2.72 | 2.72 |
| 343.38 | 2.29 | 2.29 |
| 356.45 | 4.07 | 4.07 |
| 314.35 | 1.52 | 1.52 |
| 330.41 | 3.85 | 3.85 |
| 353.40 | 4.44 | 4.44 |
| 235.29 | 2.10 | 2.10 |
| 435.55 | 4.70 | 4.70 |
| 449.55 | 4.83 | 4.83 |
| 417.60 | 2.75 | 2.75 |
| 299.37 | 2.94 | 2.94 |
| 422.49 | 3.24 | 3.24 |
| 454.57 | 2.96 | 2.96 |
| 334.44 | 3.02 | 3.02 |
| 375.43 | 4.19 | 4.19 |
| 468.51 | 3.17 | 3.17 |
| 466.65 | 4.80 | 4.80 |
| 341.36 | 3.13 | 3.13 |
| 370.84 | 4.35 | 4.35 |
| 382.45 | 3.39 | 3.39 |
| 470.93 | 5.24 | 5.24 |
| 285.35 | 2.56 | 2.56 |
| 470.60 | 4.33 | 4.33 |
| 342.40 | 3.57 | 3.57 |
| 342.42 | 3.45 | 3.45 |
| 297.31 | 2.60 | 2.60 |
| 342.40 | 2.56 | 2.56 |
| 365.39 | 2.50 | 2.50 |
| 301.39 | 3.19 | 3.19 |
| 338.42 | 3.47 | 3.47 |
| 336.40 | 3.70 | 3.70 |
| 211.25 | 1.12 | 1.12 |
| 388.24 | 2.24 | 2.24 |
| 381.46 | 3.19 | 3.19 |
| 396.47 | 2.64 | 2.64 |
| 367.41 | 2.88 | 2.88 |
| 404.51 | 3.27 | 3.27 |
| 416.50 | 4.59 | 4.59 |
| 387.49 | 3.95 | 3.95 |
| 384.52 | 3.51 | 3.51 |
| 209.21 | 0.47 | 0.47 |
| 371.82 | 3.87 | 3.87 |
| 350.42 | 4.00 | 4.00 |
| 365.39 | 3.46 | 3.46 |
| 330.39 | 0.99 | 0.99 |
| 368.23 | 4.13 | 4.13 |
| 357.84 | 4.37 | 4.37 |
| 344.42 | 1.53 | 1.53 |
| 367.40 | 3.73 | 3.73 |
| 330.39 | 1.14 | 1.14 |
| 432.57 | 5.54 | 5.54 |
| 340.38 | 3.60 | 3.60 |
| 227.27 | 2.78 | 2.78 |
| 469.97 | 3.90 | 3.90 |
| 364.27 | 4.30 | 4.30 |
| 426.42 | 3.60 | 3.60 |
| 325.41 | 3.70 | 3.70 |
| 357.45 | 4.06 | 4.06 |
| 308.34 | 2.26 | 2.26 |
| 345.42 | 3.59 | 3.59 |
| 361.40 | 3.87 | 3.87 |
| 310.36 | 2.71 | 2.71 |
| 343.38 | 2.29 | 2.29 |
| 343.38 | 1.96 | 1.96 |
| 446.55 | 3.56 | 3.56 |
| 349.39 | 3.60 | 3.60 |
| 391.49 | 5.46 | 5.46 |
| 188.23 | 2.19 | 2.19 |
| 197.22 | 0.73 | 0.73 |
| 319.43 | 2.57 | 2.57 |
| 435.57 | 5.86 | 5.86 |
| 428.49 | 4.78 | 4.78 |
| 391.43 | 3.88 | 3.88 |
| 385.51 | 2.03 | 2.03 |
| 421.52 | 3.45 | 3.45 |
| 371.44 | 3.45 | 3.45 |
| 353.38 | 3.57 | 3.57 |
| 316.40 | 1.41 | 1.41 |
| 357.87 | 3.75 | 3.75 |
| 331.39 | 3.20 | 3.20 |
| 375.25 | 4.02 | 4.02 |
| 329.38 | 3.84 | 3.84 |
| 370.50 | 3.03 | 3.03 |
| 368.89 | 4.40 | 4.40 |
| 369.49 | 4.08 | 4.08 |
| 331.40 | 3.24 | 3.24 |
| 375.43 | 4.19 | 4.19 |
| 418.50 | 4.44 | 4.44 |
| 263.34 | 2.88 | 2.88 |
| 332.36 | 3.20 | 3.20 |
| 375.38 | 4.20 | 4.20 |
| 397.54 | 5.24 | 5.24 |
| 411.89 | 4.84 | 4.84 |
| 375.47 | 4.64 | 4.64 |
| 376.42 | 3.87 | 3.87 |
| 422.51 | 4.92 | 4.92 |
| 403.51 | 3.32 | 3.32 |
| 363.41 | 3.59 | 3.59 |
| 390.49 | 2.88 | 2.88 |
| 351.40 | 3.64 | 3.64 |
| 301.35 | 1.84 | 1.84 |
| 331.39 | 3.34 | 3.34 |
| 423.51 | 4.46 | 4.46 |
| 385.51 | 2.22 | 2.22 |
| 375.50 | 4.18 | 4.18 |
| 401.85 | 3.88 | 3.88 |
| 329.38 | 2.95 | 2.95 |
| 382.21 | 3.86 | 3.86 |
| 405.50 | 4.55 | 4.55 |
| 349.82 | 3.77 | 3.77 |
| 315.35 | 2.56 | 2.56 |
| 428.51 | 3.86 | 3.86 |
| 443.48 | 5.26 | 5.26 |
| 399.52 | 3.75 | 3.75 |
| 315.42 | 3.58 | 3.58 |
| 325.44 | 4.10 | 4.10 |
| 355.46 | 4.66 | 4.66 |
| 343.43 | 3.81 | 3.81 |
| 453.59 | 3.00 | 3.00 |
| 357.41 | 4.88 | 4.88 |
| 429.90 | 4.97 | 4.97 |
| 398.55 | 3.90 | 3.90 |
| 417.51 | 3.84 | 3.84 |
| 397.43 | 1.46 | 1.46 |
| 310.36 | 2.37 | 2.37 |
| 437.52 | 3.93 | 3.93 |
| 454.55 | 5.26 | 5.26 |
| 303.34 | 2.56 | 2.56 |
| 357.41 | 2.35 | 2.35 |
| 336.40 | 3.70 | 3.70 |
| 318.44 | 3.78 | 3.78 |
| 301.37 | 3.54 | 3.54 |
| 370.50 | 3.26 | 3.26 |
| 313.38 | 3.07 | 3.07 |
| 301.39 | 3.19 | 3.19 |
| 337.81 | 4.23 | 4.23 |
| 279.37 | 2.48 | 2.48 |
| 341.46 | 4.11 | 4.11 |
| 335.41 | 4.30 | 4.30 |
| 284.32 | 2.16 | 2.16 |
| 288.35 | 2.36 | 2.36 |
| 331.35 | 3.15 | 3.15 |