Basic Information
ID: ALA4419325
Type: Toxicity
Description: Therapeutic index, ratio of LC50 for toxicity in human U937 cells assessed as reduction in cell viability incubated for 16 hrs by trypan blue dye based assay to EC50 for inhibition of LPS-induced TNFalpha production in PBMC (unknown origin) incubated for 16 hrs by ELISA
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4419325
Ratio LC50/IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 240.35 | 2.57 | 2.57 |
| 406.62 | 4.55 | 4.55 |
| 372.48 | 2.94 | 2.94 |
| 422.58 | 5.47 | 5.47 |
| 392.55 | 5.90 | 5.90 |
| 378.56 | 3.77 | 3.77 |
| 420.65 | 4.94 | 4.94 |
| 424.55 | 4.26 | 4.26 |
| 372.47 | 5.09 | 5.09 |
| 406.58 | 4.81 | 4.81 |
| 396.50 | 3.48 | 3.48 |
| 404.60 | 6.02 | 6.02 |
| 410.56 | 2.24 | 2.24 |
| 442.60 | 4.82 | 4.82 |
| 372.48 | 2.94 | 2.94 |
| 394.52 | 4.69 | 4.69 |
| 434.67 | 5.16 | 5.16 |
| 434.67 | 5.16 | 5.16 |
| 406.62 | 4.55 | 4.55 |
| 318.42 | 3.02 | 3.02 |
| 392.59 | 4.16 | 4.16 |