Assay Report Card

Basic Information

ID: ALA4419454

Type: Binding

Description: Inhibition of ferroportin in mouse J774 cells assessed as reduction in binding of hepcidin to ferroportin pre-incubated for 15 mins before TMR-hepcidin addition and further incubated for 2 hrs by fluorescence based hepcidin internalization assay

Organism: Mus musculus

Cell type: J774

Activity Charts

Bioactivity

Activity Types for Assay ALA4419454

IC50

Total(194)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
452.56	3.59	3.59
461.42	3.03	3.03
441.95	3.03	3.03
424.51	2.86	2.86
452.97	3.64	3.64
433.45	2.26	2.26
395.49	2.02	2.02
427.51	2.67	2.67
476.61	3.12	3.12
407.45	2.09	2.09
519.86	2.82	2.82
475.50	4.18	4.18
438.53	3.17	3.17
461.38	3.98	3.98
375.44	1.87	1.87
391.44	1.65	1.65
460.49	3.41	3.41
426.93	3.33	3.33
516.89	2.11	2.11
426.43	2.53	2.53
499.83	2.25	2.25
410.48	2.82	2.82
551.88	3.00	3.00
434.48	3.05	3.05
438.53	3.17	3.17
478.48	3.83	3.83
406.52	2.99	2.99
407.45	2.09	2.09
394.41	1.41	1.41
410.48	2.82	2.82
391.50	3.63	3.63
444.42	2.67	2.67
434.57	3.35	3.35
452.56	3.94	3.94
435.51	1.78	1.78
409.88	2.53	2.53
457.51	3.88	3.88
421.44	2.05	2.05
422.51	2.69	2.69
462.55	3.37	3.37
389.46	1.92	1.92
460.87	3.18	3.18
419.46	2.32	2.32
428.47	2.95	2.95
540.67	2.30	2.30
537.85	2.95	2.95
410.48	2.82	2.82
438.46	2.40	2.40
406.52	2.72	2.72
394.41	2.35	2.35
424.51	3.12	3.12
438.44	2.80	2.80
393.48	2.07	2.07
421.48	2.36	2.36
422.46	2.73	2.73
397.53	3.34	3.34
406.52	2.99	2.99
424.89	2.90	2.90
409.49	3.42	3.42
476.43	3.41	3.41
432.55	3.38	3.38
420.54	3.29	3.29
408.44	2.39	2.39
393.43	2.01	2.01
394.41	2.35	2.35
527.91	3.16	3.16
409.43	1.78	1.78
406.42	2.61	2.61
412.40	2.49	2.49
396.45	3.14	3.14
615.74	4.89	4.89
420.45	2.66	2.66
402.46	2.52	2.52
376.42	2.21	2.21
410.48	3.53	3.53
406.52	2.72	2.72
488.45	3.68	3.68
427.92	2.73	2.73
406.52	2.99	2.99
441.95	2.77	2.77
410.87	1.92	1.92
450.54	3.85	3.85
424.51	3.12	3.12
477.59	2.51	2.51
419.46	2.36	2.36
478.60	3.98	3.98
447.52	3.10	3.10
426.43	2.53	2.53
516.89	2.11	2.11
568.33	3.51	3.51
416.51	3.15	3.15
515.90	2.99	2.99
469.37	3.14	3.14
470.96	3.78	3.78
460.61	3.88	3.88
533.89	3.21	3.21
435.56	2.74	2.74
475.45	3.07	3.07
381.47	2.00	2.00
501.87	2.68	2.68
517.82	2.39	2.39
405.44	2.28	2.28
431.53	3.16	3.16
410.48	2.82	2.82
423.91	2.57	2.57
393.48	2.07	2.07
481.60	2.92	2.92
486.96	2.88	2.88
503.79	2.35	2.35
382.45	2.27	2.27
410.87	2.86	2.86
460.49	3.70	3.70
417.50	2.55	2.55
438.44	2.80	2.80
426.93	3.33	3.33
410.48	2.82	2.82
438.53	3.59	3.59
494.36	1.58	1.58
408.44	1.45	1.45
515.42	3.35	3.35
444.92	3.47	3.47
455.98	3.08	3.08
395.49	2.02	2.02
492.50	3.88	3.88
393.48	2.07	2.07
452.97	3.53	3.53
440.96	3.37	3.37
407.50	2.38	2.38
422.51	2.17	2.17
424.51	2.86	2.86
547.92	3.25	3.25
410.48	2.82	2.82
460.49	3.70	3.70
444.42	2.67	2.67
501.87	2.68	2.68
395.49	2.02	2.02
427.48	3.56	3.56
569.87	3.14	3.14
421.53	2.42	2.42
533.89	3.21	3.21
511.41	2.38	2.38
401.47	2.36	2.36
444.92	3.47	3.47
450.50	2.54	2.54
395.49	2.02	2.02
540.63	4.60	4.60
489.65	3.03	3.03
494.93	4.35	4.35
422.51	2.69	2.69
480.61	4.37	4.37
551.88	3.00	3.00
501.87	2.68	2.68
450.54	3.52	3.52
406.52	2.99	2.99
408.49	1.97	1.97
698.46	4.22	4.22
420.45	2.66	2.66
436.52	3.02	3.02
530.91	2.42	2.42
406.52	3.24	3.24
420.45	2.66	2.66
409.52	2.32	2.32
515.90	2.99	2.99
432.55	3.21	3.21
422.51	2.69	2.69
427.92	2.73	2.73
568.68	4.69	4.69
432.55	3.55	3.55
433.49	2.40	2.40
444.42	2.67	2.67
417.54	3.55	3.55
452.56	3.59	3.59
422.46	2.70	2.70
403.45	1.91	1.91
442.88	3.04	3.04
520.85	3.08	3.08
438.44	2.80	2.80
553.30	2.06	2.06
530.91	2.42	2.42
393.48	2.07	2.07
436.52	3.13	3.13
408.44	2.39	2.39
408.44	1.45	1.45
408.49	1.97	1.97
428.47	2.95	2.95
450.54	3.30	3.30
421.48	2.63	2.63
442.50	3.00	3.00
395.49	2.02	2.02
444.56	3.47	3.47
524.88	2.40	2.40
420.54	3.29	3.29
547.92	3.20	3.20
519.86	2.82	2.82